KT-362 fumarate
Code | Size | Price |
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TAR-T27753-1mg | 1mg | £330.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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TAR-T27753-5mg | 5mg | £670.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Quantity:
TAR-T27753-1mL | 1 mL * 10 mM (in DMSO) | £791.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T27753-10mg | 10mg | £914.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T27753-25mg | 25mg | £1,324.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T27753-50mg | 50mg | £1,741.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T27753-100mg | 100mg | £2,344.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
KT-362 is an antagonist of calcium channel, potassium channel and sodium channel. KT-362 has vasodilating action on intracellular calcium mobilization of atrial muscle.
CAS:
105394-80-7
Formula:
C26H32N2O7S
Molecular Weight:
516.61
Pathway:
Membrane transporter/Ion channel|Metabolism
Purity:
0.98
SMILES:
OC(=O)C=CC(O)=O.COc1ccc(CCNCCC(=O)N2CCCSc3ccccc23)cc1OC
Target:
Sodium Channel|Calcium Channel|Potassium Channel
References
1. Ueyama N, Wakabayashi S, Tomiyama T. Change of mechanical activity to contraction from the relaxation induced by the intracellular Ca2+ antagonist KT-362; effects of alkylation of side chain, and substitution of 2,3,4,5-tetrahydro-1,5-benzothiazepine derivatives. Chem Pharm Bull (Tokyo). 1997 Nov;45(11):1761-6. PubMed PMID: 9396151.
2. Tatsukawa Y, Arita M. Effects of KT-362, a sarcolemmal and intracellular calcium antagonist, on calcium transients of cultured neonatal rat ventricular cells: a comparison with gallopamil and ryanodine. Cardiovasc Drugs Ther. 1997 Jan;10(6):667-75. PubMed PMID: 9110109.
3. Erker T. [Studies on the chemistry of thieno-annealed O,N- and S,N-containing heterocyclics. 9. Synthesis and calcium channel blocking action of theino-analogs of KT-362]. Arch Pharm (Weinheim). 1995 Apr;328(4):313-6. German. PubMed PMID: 7611826.
4. Cheng YN, Kiyosue T, Arita M. Effects of KT-362, a new antiarrhythmic agent, on membrane ionic currents of guinea pig ventricular myocytes. J Pharmacol Exp Ther. 1994 Sep;270(3):851-7. PubMed PMID: 7932196.