Leucettamol A
| Code | Size | Price |
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| TAR-T27815-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Leucettamol A is a leukotriene B4 receptor antagonist isolated from the marine sponge Leucetta microraphis. It inhibits the formation of a complex composed of the ubiquitin E2 enzyme Ubc13 and Uev1A.
CAS:
151124-32-2
Formula:
C30H52N2O2
Molecular Weight:
472.758
Purity:
0.98
SMILES:
C[C@@H](N)[C@@H](O)CCCCCCC=C/CC=CCC=C/CC=C/CC=C/CC=C/C[C@H](O)[C@@H](C)N
References
1. Chen H, Wu G, Gao S, Guo R, Zhao Z, Yuan H, Liu S, Wu J, Lu X, Yuan X, Yu Z, Zu X, Xie N, Yang N, Hu Z, Sun Q, Zhang W. Discovery of Potent Small-Molecule Inhibitors of Ubiquitin-Conjugating Enzyme UbcH5c from ?-Santonin Derivatives. J Med Chem. 2017 Aug 2. doi: 10.1021/acs.jmedchem.6b01829. [Epub ahead of print] PubMed PMID: 28696694.
2. Dalisay DS, Tsukamoto S, Molinski TF. Absolute configuration of the alpha,omega bifunctionalized sphingolipid leucettamol A from Leucetta microrhaphis by deconvoluted exciton coupled CD. J Nat Prod. 2009 Mar 27;72(3):353-9. doi: 10.1021/np800549n. PubMed PMID: 19159253; PubMed Central PMCID: PMC2765480.
3. Ushiyama S, Umaoka H, Kato H, Suwa Y, Morioka H, Rotinsulu H, Losung F, Mangindaan RE, de Voogd NJ, Yokosawa H, Tsukamoto S. Manadosterols A and B, sulfonated sterol dimers inhibiting the Ubc13-Uev1A interaction, isolated from the marine sponge Lissodendryx fibrosa. J Nat Prod. 2012 Aug 24;75(8):1495-9. doi: 10.1021/np300352u. Epub 2012 Aug 8. PubMed PMID: 22873794.
4. Tsukamoto S, Takeuchi T, Rotinsulu H, Mangindaan RE, van Soest RW, Ukai K, Kobayashi H, Namikoshi M, Ohta T, Yokosawa H. Leucettamol A: a new inhibitor of Ubc13-Uev1A interaction isolated from a marine sponge, Leucetta aff. microrhaphis. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6319-20. doi: 10.1016/j.bmcl.2008.10.110. Epub 2008 Oct 31. PubMed PMID: 19006668.