LSP1-2111
Code | Size | Price |
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TAR-T27856-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T27856-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T27856-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
LSP1-2111 is a mGlu4 receptor subtype agonist.
CAS:
936234-43-4
Formula:
C12H17N2O9P
Molecular Weight:
364.247
Purity:
0.98
SMILES:
COc1cc(cc(c1O)[N+]([O-])=O)C(O)P(O)(=O)CC[C@H](N)C(O)=O
References
1. Cajina M, Nattini M, Song D, Smagin G, J?rgensen EB, Chandrasena G, Bundgaard C, Toft DB, Huang X, Acher F, Doller D. Qualification of LSP1-2111 as a Brain Penetrant Group III Metabotropic Glutamate Receptor Orthosteric Agonist. ACS Med Chem Lett. 2013 Dec 12;5(2):119-23. doi: 10.1021/ml400338f. PubMed PMID: 24900783; PubMed Central PMCID: PMC4027608.
2. Wiero?ska JM, Acher FC, S?awi?ska A, Gruca P, Laso?-Tyburkiewicz M, Papp M, Pilc A. The antipsychotic-like effects of the mGlu group III orthosteric agonist, LSP1-2111, involves 5-HT?A signalling. Psychopharmacology (Berl). 2013 Jun;227(4):711-25. doi: 10.1007/s00213-013-3005-0. PubMed PMID: 23474845; PubMed Central PMCID: PMC3663209.
3. Wiero?ska JM, Stachowicz K, Acher F, Lech T, Pilc A. Opposing efficacy of group III mGlu receptor activators, LSP1-2111 and AMN082, in animal models of positive symptoms of schizophrenia. Psychopharmacology (Berl). 2012 Apr;220(3):481-94. doi: 10.1007/s00213-011-2502-2. PubMed PMID: 21952670; PubMed Central PMCID: PMC3299972.
4. Wiero?ska JM, Stachowicz K, Pa?ucha-Poniewiera A, Acher F, Bra?ski P, Pilc A. Metabotropic glutamate receptor 4 novel agonist LSP1-2111 with anxiolytic, but not antidepressant-like activity, mediated by serotonergic and GABAergic systems. Neuropharmacology. 2010 Dec;59(7-8):627-34. doi: 10.1016/j.neuropharm.2010.08.008. PubMed PMID: 20713068.