LY 53857
| Code | Size | Price |
|---|
| TAR-T27921-5mg | 5mg | £1,171.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T27921-50mg | 50mg | £2,303.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T27921-100mg | 100mg | £3,042.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
LY 53857 is a potent and selective antagonist of 5-HT2 serotonin receptor.
CAS:
60634-51-7
Formula:
C27H36N2O7
Molecular Weight:
500.592
Purity:
0.98
SMILES:
OC(=O)C=C/C(O)=O.[H][C@@]12Cc3cn(C(C)C)c4cccc(c34)[C@@]1([H])C[C@@H](CN2C)C(=O)OC(C)C(C)O
References
1. Polo PA, Reis RO, Cedraz-Mercez PL, Cavalcante-Lima HR, Olivares EL, Medeiros MA, C?rtes WS, Reis LC. Behavioral and neuropharmacological evidence that serotonin crosses the blood-brain barrier in Coturnix japonica (Galliformes; Aves). Braz J Biol. 2007 Feb;67(1):167-71. PubMed PMID: 17505765.
2. Ni W, Fink GD, Watts SW. The 5-hydroxytryptamine2A receptor is involved in (+)-norfenfluramine-induced arterial contraction and blood pressure increase in deoxycorticosterone acetate-salt hypertension. J Pharmacol Exp Ther. 2007 May;321(2):485-91. Epub 2007 Feb 8. PubMed PMID: 17289838.
3. Lee JK, Johnson CS, Wrathall JR. Up-regulation of 5-HT2 receptors is involved in the increased H-reflex amplitude after contusive spinal cord injury. Exp Neurol. 2007 Feb;203(2):502-11. Epub 2006 Oct 23. PubMed PMID: 17059818; PubMed Central PMCID: PMC1859857.
4. Cedraz-Mercez PL, Almeida AC, Costa-e-Sousa RH, Badau?-Passos J?nior D, Castilhos LR, Olivares EL, Marinho J?nior A, Medeiros MA, Reis LC. Influence of serotonergic transmission anD postsynaptic 5-HT2C action on the feeding behavior of Coturnix japonica (Galliformes: Aves). Braz J Biol. 2005 Nov;65(4):589-95. PubMed PMID: 16532182.