LY2881835
Code | Size | Price |
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TAR-T27937-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T27937-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T27937-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
LY2881835 is a potent and selective GPR40 agonist.
CAS:
1292290-38-0
Formula:
C33H35NO3
Molecular Weight:
493.647
Purity:
0.98
SMILES:
CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc(CN3CCC4(CCc5ccccc45)CC3)cc2)cc1
References
1. Krasavin M, Lukin A, Bagnyukova D, Zhurilo N, Zahanich I, Zozulya S. Novel FFA1 (GPR40) agonists containing spirocyclic periphery: polar azine periphery as a driver of potency. J Enzyme Inhib Med Chem. 2016 Oct 26:1-8. [Epub ahead of print] PubMed PMID: 27781494.
2. Hamdouchi C, Kahl SD, Patel Lewis A, Cardona GR, Zink RW, Chen K, Eessalu TE, Ficorilli JV, Marcelo MC, Otto KA, Wilbur KL, Lineswala JP, Piper JL, Coffey DS, Sweetana SA, Haas JV, Brooks DA, Pratt EJ, Belin RM, Deeg MA, Ma X, Cannady EA, Johnson JT, Yumibe NP, Chen Q, Maiti P, Montrose-Rafizadeh C, Chen Y, Reifel Miller A. The Discovery, Preclinical and Early Clinical Development of Potent and Selective GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus (LY2881835, LY2922083 and LY2922470). J Med Chem. 2016 Oct 17. [Epub ahead of print] PubMed PMID: 27749056.
3. Krasavin M, Lukin A, Bagnyukova D, Zhurilo N, Zahanich I, Zozulya S, Ihalainen J, Forsberg MM, Lehtonen M, Rautio J, Moore D, Tikhonova IG. Free fatty acid receptor 1 (GPR40) agonists containing spirocyclic periphery inspired by LY2881835. Bioorg Med Chem. 2016 Nov 1;24(21):5481-5494. doi: 10.1016/j.bmc.2016.09.004. PubMed PMID: 27647366.