M199
| Code | Size | Price |
|---|
| TAR-T27967-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T27967-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T27967-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
M199, a novel inhibitor of TLR3/9 activation, induces secretion of IL-6, IL-8 and TNFalpha in human PBMCs.
CAS:
1051933-86-8
Formula:
C17H17N3O
Molecular Weight:
279.343
Purity:
0.98
SMILES:
CCNC(=O)Nc1ccc2c(c1)c(C)nc1ccccc21
References
1. Talepoor AG, Kalani M, Dahaghani AS, Doroudchi M. Hydrogen Peroxide and Lipopolysaccharide Differentially Affect the Expression of MicroRNAs 10a, 33a, 21, 221 in Endothelial Cells Before and After Coculture With Monocytes. Int J Toxicol. 2017 Mar/Apr;36(2):133-141. doi: 10.1177/1091581817695270. PubMed PMID: 28403739.
2. Yao Q, Song R, Ao L, Cleveland JC Jr, Fullerton DA, Meng X. Neurotrophin 3 up-regulates proliferation and collagen production in human aortic valve interstitial cells: a potential role in aortic valve sclerosis. Am J Physiol Cell Physiol. 2017 Mar 29:ajpcell.00292.2016. doi: 10.1152/ajpcell.00292.2016. [Epub ahead of print] PubMed PMID: 28356268.
3. Teofilovi? NK, Bihi M, Stojkovi? MR, Tumir LM, Ester K, Kralj M, Majhen D, Or?oli? N, Lepur A, Vrbanec D, Markoti? A, Dembi? Z, Weber AN, Piantanida I, Vugrek O, Diken M, Kne?evi? J. 1-ethyl-3-(6-methylphenanthridine-8-il) urea modulates TLR3/9 activation and induces selective pro-inflammatory cytokine expression in vitro. Bioorg Med Chem Lett. 2017 Apr 1;27(7):1530-1537. doi: 10.1016/j.bmcl.2017.02.048. Epub 2017 Feb 20. PubMed PMID: 28254484.
4. Canesin HS, Brom-de-Luna JG, Choi YH, Ortiz I, Diaw M, Hinrichs K. Blastocyst development after intracytoplasmic sperm injection of equine oocytes vitrified at the germinal-vesicle stage. Cryobiology. 2017 Apr;75:52-59. doi: 10.1016/j.cryobiol.2017.02.004. Epub 2017 Feb 13. PubMed PMID: 28209499.