M-5011
| Code | Size | Price |
|---|
| TAR-T27968-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
M-5011 is a non-steroidal anti-inflammatory drug and immunomodulator potentially for the treatment of inflammation and pain. M-5011 had an effective antinociceptive activity (ED50 value) of 0.63 mg/kg. M-5011 partially inhibits the generalized bone loss accompanying the development of collagen-induced arthritis in rats. M-5011 is a useful NSAID that shows potent antinociceptive effects with low ulcerogenic activities.
CAS:
76604-64-3
Formula:
C14H14O2S
Molecular Weight:
246.32
Purity:
0.98
SMILES:
C[C@@H](C(O)=O)c1ccc(cc1)-c1sccc1C
References
1. Horisawa E, Danjo K, Haruna M. Physical properties of solid dispersion of a nonsteroidal anti-inflammatory drug (M-5011) with Eudragit E. Drug Dev Ind Pharm. 2000 Dec;26(12):1271-8. PubMed PMID: 11147127.
2. Taguchi K, Konishi T, Nishikawa H, Kitamura S. Identification of human cytochrome P450 isoforms involved in the metabolism of S-2-[4-(3-methyl-2-thienyl)phenyl]propionic acid. Xenobiotica. 1999 Sep;29(9):899-907. PubMed PMID: 10548450.
3. Murakami N, Aihara S, Iwata K, Saito T, Naruse T. Effect of a novel non-steroidal anti-inflammatory drug (M-5011) on cytokine levels in rats with monosodium urate crystal- induced pleurisy. Jpn J Pharmacol. 1999 Apr;79(4):439-46. PubMed PMID: 10361883.
4. Konishi T, Nishikawa H, Kitamura S, Tatsumi K. In vivo studies on chiral inversion and amino acid conjugation of 2-[4-(3-methyl-2-thienyl)phenyl]propionic acid in rats and dogs. Drug Metab Dispos. 1999 Jan;27(1):158-60. PubMed PMID: 9884325.