MC-70
| Code | Size | Price |
|---|
| TAR-T27985-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T27985-50mg | 50mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
MC-70 is a potent P-glycoprotein (P-gp) inhibitor (EC50 = 0.69 μM).
CAS:
1031367-64-2
Formula:
C24H25NO3
Molecular Weight:
375.468
Purity:
0.98
SMILES:
COc1cc2CCN(Cc3ccc(cc3)-c3ccc(O)cc3)Cc2cc1OC
References
1. Guglielmo S, Lazzarato L, Contino M, Perrone MG, Chegaev K, Carrieri A, Fruttero R, Colabufo NA, Gasco A. SAR Studies on Tetrahydroisoquinoline Derivatives: [4'-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl)biphenyl-4-ol] (MC70(1)) Conjugated Through Flexible Alkyl Chains with Furazan Moieties Gives Rise to Potent and Selective Ligands of P-glycoprotein. J Med Chem. 2016 Jun 23. [Epub ahead of print] PubMed PMID: 27336199.
2. Guglielmo S, Contino M, Lazzarato L, Perrone MG, Blangetti M, Fruttero R, Colabufo NA. A Potent and Selective P-gp Modulator for Altering Multidrug Resistance Due to Pump Overexpression. ChemMedChem. 2016 Feb 17;11(4):374-6. doi: 10.1002/cmdc.201500538. Epub 2016 Jan 21. PubMed PMID: 26797828.
3. Capparelli E, Contino M, Perrone MG, Berardi F, Perrone R, Leopoldo M, Colabufo NA. Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands. Arch Pharm (Weinheim). 2016 Mar;349(3):161-7. doi: 10.1002/ardp.201500325. Epub 2016 Jan 11. PubMed PMID: 26750618.
4. Chopra A. O-[(11)C]methyl derivative of 6,7-dimethoxy-2-(4-methoxy-biphenyl-4-yl-methyl)-1,2,3,4-tetrahydro-isoquinoline. 2012 Nov 05 [updated 2013 Jan 31]. Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013. Available from http://www.ncbi.nlm.nih.gov/books/NBK116755/ PubMed PMID: 23390669.