MDK-4624
| Code | Size | Price |
|---|
| TAR-T27999-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T27999-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T27999-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
MDK-4624 is a AMPKα1 activator. MDK-4624 inhibits Helicobacter pylori-induced oxidative stresses and gastric epithelial cell apoptosis. MDK-4624 attenuates dexamethasone-induced osteoblast cell death. MDK-4624 potently inhibits melanoma cell proliferation.
CAS:
1243184-62-4
Formula:
C17H22NO10P
Molecular Weight:
431.334
Purity:
0.98
SMILES:
CC(C)C(=O)OCOP(=O)(OCOC(=O)C(C)C)c1ccc(o1)C1=NOC(=O)C1
References
1. Zhou C, Gu J, Zhang G, Dong D, Yang Q, Chen MB, Xu D. AMPK-autophagy inhibition sensitizes icaritin-induced anti-colorectal cancer cell activity. Oncotarget. 2017 Feb 28;8(9):14736-14747. doi: 10.18632/oncotarget.14718. PubMed PMID: 28103582; PubMed Central PMCID: PMC5362439.
2. Guo S, Mao L, Ji F, Wang S, Xie Y, Fei H, Wang XD. Activating AMP-activated protein kinase by an ?1 selective activator compound 13 attenuates dexamethasone-induced osteoblast cell death. Biochem Biophys Res Commun. 2016 Mar 18;471(4):545-52. doi: 10.1016/j.bbrc.2016.02.036. Epub 2016 Feb 15. PubMed PMID: 26891866.
3. Hu X, Jiang F, Bao Q, Qian H, Fang Q, Shao Z. Compound 13, an ?1-selective small molecule activator of AMPK, potently inhibits melanoma cell proliferation. Tumour Biol. 2016 Jan;37(1):1071-8. doi: 10.1007/s13277-015-3854-8. Epub 2015 Aug 14. PubMed PMID: 26271666.
4. Zhao H, Zhu H, Lin Z, Lin G, Lv G. Compound 13, an ?1-selective small molecule activator of AMPK, inhibits Helicobacter pylori-induced oxidative stresses and gastric epithelial cell apoptosis. Biochem Biophys Res Commun. 2015 Aug 7;463(4):510-7. doi: 10.1016/j.bbrc.2015.05.059. Epub 2015 May 27. PubMed PMID: 26022128.