MDK8228
Code | Size | Price |
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TAR-T28004-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T28004-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T28004-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
MDK8228 is an inhibitor of CBP/p300 and BRD4 bromodomain. MDK8228 downregulates IL-6, IL-? and IFN-? in macrophages.
CAS:
1962928-22-8
Formula:
C31H41N5O3
Molecular Weight:
531.701
Purity:
0.98
SMILES:
CN(C)CCCOc1ccc(CCc2nc3cc(ccc3n2CCN2CCOCC2)-c2c(C)noc2C)cc1
References
1. Ummarino D. Heart failure: BRD4 inhibition slows HF progression. Nat Rev Cardiol. 2017 Jun 1. doi: 10.1038/nrcardio.2017.86. [Epub ahead of print] PubMed PMID: 28569271.
2. Heinzelmann G, Henriksen NM, Gilson MK. Attach-pull-release calculations of ligand binding and conformational changes on the first BRD4 bromodomain. J Chem Theory Comput. 2017 May 31. doi: 10.1021/acs.jctc.7b00275. [Epub ahead of print] PubMed PMID: 28564537.
3. Amemiya S, Yamaguchi T, Hashimoto Y, Noguchi-Yachide T. Synthesis and evaluation of novel dual BRD4/HDAC inhibitors. Bioorg Med Chem. 2017 May 17. pii: S0968-0896(17)30764-2. doi: 10.1016/j.bmc.2017.04.043. [Epub ahead of print] PubMed PMID: 28549889.
4. Pongas G, Kim MK, Min DJ, House CD, Jordan E, Caplen N, Chakka S, Ohiri J, Kruhlak MJ, Annunziata CM. BRD4 facilitates DNA damage response and represses CBX5/Heterochromatin protein 1 (HP1). Oncotarget. 2017 May 3. doi: 10.18632/oncotarget.17572. [Epub ahead of print] PubMed PMID: 28548929.