ME-3221
| Code | Size | Price |
|---|
| TAR-T28009-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T28009-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T28009-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Apomine is an inhibitor of HMG-CoA-reductase. It promotes apoptosis of myeloma cells in vitro and is associated with a modulation of myeloma in vivo. Apomine enhances the antitumor effects of lovastatin on myeloma cells by down-regulating 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Apomine accelerates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and stimulates low density lipoprotein receptor activity.
CAS:
139958-16-0
Formula:
C22H21N5O2
Molecular Weight:
387.443
Purity:
0.98
SMILES:
COc1c(C)nc(C)cc1OCc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
References
1. Kawano K, Fujishima K, Nagura J, Yasuda S, Shinki, Hachisu M, Konno F. Nonpeptide angiotensin II receptor antagonist recognizes inter-species differences in angiotensin AT1 receptors. Eur J Pharmacol. 1998 Sep 11;357(1):33-9. PubMed PMID: 9788771.
2. Nagura J, Hui C, Yamamoto M, Yasuda S, Abe M, Hachisu M, Konno F. ME3221, a surmountable angiotensin AT1-receptor antagonist, prevents hypertensive complications in aged stroke-prone spontaneously hypertensive rats. Jpn J Pharmacol. 1996 May;71(1):39-49. PubMed PMID: 8791170.
3. Nagura J, Yamamoto M, Hui C, Yasuda S, Hachisu M, Konno F. Protective effects of ME3221 on hypertensive complications and lifespan in salt-loaded stroke-prone spontaneously hypertensive rats. Clin Exp Pharmacol Physiol. 1996 Mar;23(3):229-35. PubMed PMID: 8934613.
4. Nagura J, Yasuda S, Fujishima K, Yamamoto M, Hui C, Kawano K, Katano K, Ogino H, Hachisu M, Konno F. Pharmacological profile of ME3221, a novel angiotensin II receptor antagonist. Eur J Pharmacol. 1995 Feb 14;274(1-3):201-11. PubMed PMID: 7768273.