TargetMol

meso-Dihydroguaiaretic acid

Product Code:
 
TAR-T28021
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T28021-5mg5mg£850.00
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Further Information

Bioactivity:
meso-Dihydroguaiaretic acid is an LXR-α antagonist, it inhibits hepatic lipid accumulation by activating AMP-activated protein kinase in human HepG2 cells.
CAS:
36469-60-0
Formula:
C20H26O4
Molecular Weight:
330.42
Purity:
0.98
SMILES:
OC1=CC=C(C[C@@H](C)[C@@H](C)CC2=CC=C(O)C(OC)=C2)C=C1OC

References

1. Lee A, Choi KM, Jung WB, Jeong H, Kim GY, Lee JH, Lee MK, Hong JT, Roh YS, Sung SH, Yoo HS. Enhancement of Glucose Uptake by Meso-Dihydroguaiaretic Acid through GLUT4 Up-Regulation in 3T3-L1 Adipocytes. Molecules. 2017 Aug 28;22(9). pii: E1423. doi: 10.3390/molecules22091423. PubMed PMID: 28846649. 2. Reyes-Melo K, Garc?a A, Romo-Mancillas A, Garza-Gonz?lez E, Rivas-Galindo VM, Miranda LD, Vargas-Villarreal J, Favela-Hern?ndez JMJ, Camacho-Corona MDR. meso-Dihydroguaiaretic acid derivatives with antibacterial and antimycobacterial activity. Bioorg Med Chem. 2017 Oct 15;25(20):5247-5259. doi: 10.1016/j.bmc.2017.07.047. Epub 2017 Jul 29. PubMed PMID: 28844400. 3. Nishiwaki H, Nakazaki S, Akiyama K, Yamauchi S. Structure-Antifungal Activity Relationship of Fluorinated Dihydroguaiaretic Acid Derivatives and Preventive Activity against Alternaria alternata Japanese Pear Pathotype. J Agric Food Chem. 2017 Aug 9;65(31):6701-6707. doi: 10.1021/acs.jafc.7b01896. Epub 2017 Jul 26. PubMed PMID: 28681599. 4. Vuorinen A, Engeli RT, Leugger S, Bachmann F, Akram M, Atanasov AG, Waltenberger B, Temml V, Stuppner H, Krenn L, Ateba SB, Njamen D, Davis RA, Odermatt A, Schuster D. Potential Antiosteoporotic Natural Product Lead Compounds That Inhibit 17?-Hydroxysteroid Dehydrogenase Type 2. J Nat Prod. 2017 Apr 28;80(4):965-974. doi: 10.1021/acs.jnatprod.6b00950. Epub 2017 Mar 20. PubMed PMID: 28319389; PubMed Central PMCID: PMC5411959.