Metacavir
| Code | Size | Price |
|---|
| TAR-T28022-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T28022-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T28022-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Metacavir, a reverse transcriptase inhibitor, is used potentially for the treatment of HBV infection.
CAS:
120503-45-9
Formula:
C11H15N5O3
Molecular Weight:
265.273
Purity:
0.98
SMILES:
COc1nc(N)nc2n(cnc12)[C@H]1CC[C@@H](CO)O1
References
1. Luo Q, Chen Z, Cheng A, Wang M, Fang J, Peng X, Tang L. Reproductive toxicity study with a novel deoxyguanosine analogue (Metacavir) in pregnant SD rats. Front Med. 2015 Mar;9(1):82-9. doi: 10.1007/s11684-015-0376-0. PubMed PMID: 25523750.
2. Zhang Y, Huang X, Jiang Z, Huang X, Hu Y, Zhu D, Zhang S, Wang J, Zhang L. Simultaneous determination of metacavir and its metabolites in rat plasma using high-performance liquid chromatography with tandem mass spectrometric detection (LC-MS/MS). Biomed Chromatogr. 2012 Mar;26(3):363-70. doi: 10.1002/bmc.1667. PubMed PMID: 21773980.
3. Zeng W, Cheng AC, Chen ZL, Luo QH, Sun YB, Li Z, Bi FJ. In vivo assessment of mitochondrial toxicity of metacavir in Rhesus monkeys after three months of intravenous administration. Acta Pharmacol Sin. 2009 Dec;30(12):1666-73. doi: 10.1038/aps.2009.163. PubMed PMID: 19915582; PubMed Central PMCID: PMC4007497.
4. Chen ZL, Zeng W, Cheng AC, Luo QH, Li Z, Peng X, Fang J, Pan KC, He M, Tang L. Six-month repeated dose toxicity of orally administered metacavir in rhesus monkeys. Exp Toxicol Pathol. 2011 May;63(4):379-85. doi: 10.1016/j.etp.2010.02.014. PubMed PMID: 20347583.