Mycinamicin I
| Code | Size | Price |
|---|
| TAR-T28121-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Mycinamicin I is a macrolide antibiotic.
CAS:
73665-15-3
Formula:
C37H61NO12
Molecular Weight:
711.89
Purity:
0.98
SMILES:
CC[C@H]1OC(=O)C=C[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@H](C)C[C@@H](C)C(=O)C=CC2OC2[C@@H]1CO[C@@H]1O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]1OC
References
1. Li S, Tietz DR, Rutaganira FU, Kells PM, Anzai Y, Kato F, Pochapsky TC, Sherman DH, Podust LM. Substrate recognition by the multifunctional cytochrome P450 MycG in mycinamicin hydroxylation and epoxidation reactions. J Biol Chem. 2012 Nov 2;287(45):37880-90. doi: 10.1074/jbc.M112.410340. Epub 2012 Sep 5. PubMed PMID: 22952225; PubMed Central PMCID: PMC3488060.
2. DeMars MD 2nd, Sheng F, Park SR, Lowell AN, Podust LM, Sherman DH. Biochemical and Structural Characterization of MycCI, a Versatile P450 Biocatalyst from the Mycinamicin Biosynthetic Pathway. ACS Chem Biol. 2016 Sep 16;11(9):2642-54. doi: 10.1021/acschembio.6b00479. Epub 2016 Aug 5. PubMed PMID: 27420774; PubMed Central PMCID: PMC5026600.
3. Anzai Y, Tsukada S, Sakai A, Masuda R, Harada C, Domeki A, Li S, Kinoshita K, Sherman DH, Kato F. Function of cytochrome P450 enzymes MycCI and MycG in Micromonospora griseorubida, a producer of the macrolide antibiotic mycinamicin. Antimicrob Agents Chemother. 2012 Jul;56(7):3648-56. doi: 10.1128/AAC.06063-11. Epub 2012 Apr 30. PubMed PMID: 22547618; PubMed Central PMCID: PMC3393388.
4. Tsukada S, Anzai Y, Li S, Kinoshita K, Sherman DH, Kato F. Gene targeting for O-methyltransferase genes, mycE and mycF, on the chromosome of Micromonospora griseorubida producing mycinamicin with a disruption cassette containing the bacteriophage phi C31 attB attachment site. FEMS Microbiol Lett. 2010 Mar;304(2):148-56. doi: 10.1111/j.1574-6968.2010.01899.x. Epub 2010 Jan 11. PubMed PMID: 20158522.