NaV1.7 Blocker-801
| Code | Size | Price |
|---|
| TAR-T28132-5mg | 5mg | £1,091.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T28132-50mg | 50mg | £2,143.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T28132-100mg | 100mg | £2,801.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
NaV1.7 Blocker-801 is a potent NaV1.7 blocker.
CAS:
1235403-75-4
Formula:
C20H15ClF2N6O3S2
Molecular Weight:
524.95
Purity:
0.98
SMILES:
Fc1cc(c(F)cc1Oc1ccc(Cl)cc1-c1ccnn1C1CNC1)S(=O)(=O)Nc1ncns1
References
1. Huang J, Vanoye CG, Cutts A, Goldberg YP, Dib-Hajj SD, Cohen CJ, Waxman SG, George AL Jr. Sodium channel NaV1.9 mutations associated with insensitivity to pain dampen neuronal excitability. J Clin Invest. 2017 May 22. pii: 92373. doi: 10.1172/JCI92373. [Epub ahead of print] PubMed PMID: 28530638.
2. Sun H, Kollarik M, Undem BJ. Blocking voltage-gated sodium channels as a strategy to suppress pathological cough. Pulm Pharmacol Ther. 2017 May 15. pii: S1094-5539(17)30112-8. doi: 10.1016/j.pupt.2017.05.010. [Epub ahead of print] Review. PubMed PMID: 28522215.
3. Zhang X, Priest BT, Belfer I, Gold MS. Voltage-gated Na(+) currents in human dorsal root ganglion neurons. Elife. 2017 May 16;6. pii: e23235. doi: 10.7554/eLife.23235. PubMed PMID: 28508747; PubMed Central PMCID: PMC5433841.
4. Low SA, Robbins W, Tawfik VL. Complex management of a patient with refractory primary erythromelalgia lacking a SCN9A mutation. J Pain Res. 2017 Apr 27;10:973-977. doi: 10.2147/JPR.S129661. eCollection 2017. PubMed PMID: 28490900; PubMed Central PMCID: PMC5414616.