NC-1300-B
Code | Size | Price |
---|
TAR-T28136-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T28136-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T28136-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
NC-1300-B is a proton pump. H(+)-K(+)-ATPase inhibition with NC-1300-B causes profound renal vasodilation and inhibition of renin release without affecting regulation of GFR.
CAS:
104340-52-5
Formula:
C17H19N3OS
Molecular Weight:
313.42
Purity:
0.98
SMILES:
CN(C)c1ccccc1CS(=O)c1nc2ccc(C)cc2[nH]1
References
1. Lin H, Young DB. Reduction in renin release and renal vascular resistance by H(+)-K(+)-ATPase inhibition. Am J Physiol. 1997 Sep;273(3 Pt 2):F457-62. PubMed PMID: 9321920.
2. Rhoden KJ, Tallini G, Douglas JS. H+-K+ ATPase inhibitors cause relaxation of guinea pig and human airway smooth muscle in vitro. J Pharmacol Exp Ther. 1996 Mar;276(3):897-903. PubMed PMID: 8786567.
3. McCabe RD, Young DB. Evidence of a K(+)-H(+)-ATPase in vascular smooth muscle cells. Am J Physiol. 1992 Jun;262(6 Pt 2):H1955-8. PubMed PMID: 1320341.
4. Okabe S, Akimoto Y, Yamasaki S, Nagai H. Effects of NC-1300-B, a new benzimidazole derivative, on hog gastric H+, K+-ATPase, gastric acid secretion and HCl.ethanol-induced gastric lesions in rats. Dig Dis Sci. 1988 Nov;33(11):1425-34. PubMed PMID: 2846250.