Cryptotanshinone
Code | Size | Price |
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TAR-T2814-10mg | 10mg | £107.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T2814-1mL | 1 mL * 10 mM (in DMSO) | £111.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T2814-25mg | 25mg | £144.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T2814-50mg | 50mg | £193.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T2814-100mg | 100mg | £265.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
Cryptotanshinone, a STAT3 inhibitor (IC50: 4.6 μM) in a cell-free assay, strongly inhibits phosphorylation of STAT3 Tyr705, with a little effect on STAT3 Ser727, but no inhibition for STAT1 nor STAT5.
CAS:
35825-57-1
Formula:
C19H20O3
Molecular Weight:
296.366
Pathway:
Stem Cells; Autophagy; JAK/STAT signaling
Purity:
0.9992
SMILES:
C[C@H]1COC2=C1C(=O)C(=O)c1c3CCCC(C)(C)c3ccc21
Target:
STAT; Autophagy
References
1. Shin DS, et al. Cancer Res, 2009, 69(1), 193-202.
2. Kim EJ, et al. Mol Pharmacol, 2007, 72(1), 62-72.
3. Chen C, Lu M, Lin S, et al. The nuclear gene rpl18 regulates erythroid maturation via JAK2-STAT3 signaling in zebrafish model of Diamond?Blackfan anemia[J]. Cell Death & Disease. 2020, 11(2): 1-11.
4. Han P, Hou Y, Zhao Y, et al. Low-dose decitabine modulates T cell homeostasisand restores immune tolerance in immune thrombocytopenia[J]. Blood. 2021