NCG21
| Code | Size | Price |
|---|
| TAR-T28140-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
NCG21 is a GPR120 agonist, which showed potent extracellular signal-regulated kinase (ERK) activation in a cloned GPR120 system. NCG21 potently activated ERK, intracellular calcium responses and GLP-1 secretion in murine enteroendocrine STC-1 cells that express GPR120 endogenously. Administration of NCG21 into the mouse colon caused an increase in plasma GLP-1 levels.
CAS:
1079821-35-4
Formula:
C23H24N2O3
Molecular Weight:
376.46
Purity:
0.98
SMILES:
O=C(O)CCCC1=CC=C(OCCN(C2=CC=CC=C2)C3=NC=CC=C3)C=C1
References
1. Sun Q, Hirasawa A, Hara T, Kimura I, Adachi T, Awaji T, Ishiguro M, Suzuki T, Miyata N, Tsujimoto G. Structure-activity relationships of GPR120 agonists based on a docking simulation. Mol Pharmacol. 2010 Nov;78(5):804-10. doi: 10.1124/mol.110.066324. Epub 2010 Aug 4. PubMed PMID: 20685848.