NCX-6560
Code | Size | Price |
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TAR-T28142-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T28142-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T28142-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
DRF 2519 is an activator of PPAR-alpha and PPAR-gamma.
CAS:
803728-45-2
Formula:
C37H42FN3O8
Molecular Weight:
675.754
Purity:
0.98
SMILES:
CC(C)c1c(C(=O)Nc2ccccc2)c(c(-c2ccc(F)cc2)n1CC[C@@H](O)C[C@@H](O)CC(=O)OCCCCO[N+]([O-])=O)-c1ccccc1
References
1. Momi S, Impagnatiello F, Guzzetta M, Caracchini R, Guglielmini G, Olivieri R, Monopoli A, Gresele P. NCX 6560, a nitric oxide-releasing derivative of atorvastatin, inhibits cholesterol biosynthesis and shows anti-inflammatory and anti-thrombotic properties. Eur J Pharmacol. 2007 Sep 10;570(1-3):115-24. PubMed PMID: 17632098.
2. Rodr?guez S, Raurell I, Torres-Arauz M, Garc?a-Lezana T, Genesc? J, Martell M. A Nitric Oxide-Donating Statin Decreases Portal Pressure with a Better Toxicity Profile than Conventional Statins in Cirrhotic Rats. Sci Rep. 2017 Jan 13;7:40461. doi: 10.1038/srep40461. PubMed PMID: 28084470; PubMed Central PMCID: PMC5233977.
3. Baetta R, Granata A, Miglietta D, Oliva F, Arnaboldi L, Bonomo A, Ferri N, Ongini E, Bellosta S, Corsini A. Nitric oxide-donating atorvastatin attenuates neutrophil recruitment during vascular inflammation independent of changes in plasma cholesterol. Cardiovasc Drugs Ther. 2013 Jun;27(3):211-9. doi: 10.1007/s10557-013-6445-1. PubMed PMID: 23400638.
4. D'Antona G, Mascaro A, Monopoli A, Miglietta D, Ongini E, Bottinelli R. Nitric oxide prevents atorvastatin-induced skeletal muscle dysfunction and alterations in mice. Muscle Nerve. 2013 Jan;47(1):72-80. doi: 10.1002/mus.23465. PubMed PMID: 23042511.