Nepaprazole
| Code | Size | Price |
|---|
| TAR-T28156-5mg | 5mg | £1,091.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T28156-50mg | 50mg | £2,143.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T28156-100mg | 100mg | £2,801.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Nepaprazole is a proton pump inhibitor. TY-11345 potently inhibited H+/K(+)-ATPase activity in isolated rabbit gastric mucosal microsomes, and the inhibitory effect was enhanced under weak acid conditions, the IC50 being 5.8 microM and 9.9 microM at pH 6.0 and pH 7.4, respectively.
CAS:
156601-79-5
Formula:
C18H19N3O2S
Molecular Weight:
341.43
Purity:
0.98
SMILES:
COc1ccnc2[C@@H](CCCCc12)S(=O)c1nc2ccccc2[nH]1
References
1. Yamada S, Goto T, Yuasa S, Yamaguchi T, Kogi K. [Synthesis of stable solvates of monosodium 2-[R*s,9S*)-(4-methoxy-6,7,8, 9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl)sulfinyl]-1H-benzimidazole]. Yakugaku Zasshi. 1996 Aug;116(8):657-70. Japanese. PubMed PMID: 8831267.
2. Yamada S, Goto T, Yamaguchi T, Aihara K, Kogi K, Narita S. Synthetic study of 2-[(6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9- yl)-sulfinyl]-1H-benzimidazole analogs and their biological properties as novel proton pump inhibitors. Chem Pharm Bull (Tokyo). 1995 Mar;43(3):421-31. PubMed PMID: 7774025.
3. Uematsu T, Nakano M, Kosuge K, Nagai A, Sato A, Nakashima M. Pharmacokinetic properties of a novel gastric proton pump inhibitor, (+/-)-2-[(4-methoxy-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9- yl)sulfinyl]-1H-benzimidazole sodium salt, in healthy subjects. J Pharm Sci. 1994 Oct;83(10):1407-11. PubMed PMID: 7884660.
4. Yamada S, Goto T, Shimanuki E, Narita S. Synthesis and antiulcer activities of novel 2-[(6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl)sulfinyl]-1H- benzimidazole analogues. Chem Pharm Bull (Tokyo). 1994 Mar;42(3):718-20. PubMed PMID: 8004722.