Niguldipine hydrochloride
| Code | Size | Price |
|---|
| TAR-T28172-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T28172-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T28172-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Niguldipine is a calcium channel antagonist. Niguldipine shows high affinity to Ca2+ channels and to a subtype of alpha 1-adrenoceptors.
CAS:
134886-09-2
Formula:
C36H40ClN3O6
Molecular Weight:
646.18
Purity:
0.98
SMILES:
Cl.COC(=O)C1=C(C)NC(C)=C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1
References
1. Kreiner G, Roman A, Zelek-Molik A, Kowalska M, Nalepa I. A lack of ?1A-adrenergic receptor-mediated antidepressant-like effects of S-(+)-niguldipine and B8805-033 in the forced swim test. Behav Pharmacol. 2016 Jun;27(4):397-401. doi: 10.1097/FBP.0000000000000204. PubMed PMID: 26588212.
2. Zhou XF, Wang Q, Coburn RA, Morris ME. A high-performance liquid chromatographic method for determination of the niguldipine analogue DHP-014. Biomed Chromatogr. 2006 Jan;20(1):48-53. PubMed PMID: 15954160.
3. Borowicz KK, Kleinrok Z, Czuczwar SJ. Niguldipine impairs the protective activity of carbamazepine and phenobarbital in amygdala-kindled seizures in rats. Eur Neuropsychopharmacol. 2002 Jun;12(3):225-33. PubMed PMID: 12007674.
4. Borowicz KK, Gasior M, Kleinrok Z, Czuczwar SJ. Influence of isradipine, niguldipine and dantrolene on the anticonvulsive action of conventional antiepileptics in mice. Eur J Pharmacol. 1997 Mar 26;323(1):45-51. PubMed PMID: 9105875.