Okicenone
| Code | Size | Price |
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| TAR-T28228-5mg | 5mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Okicenone is an antibiotic, interferring with HuR RNA binding, HuR trafficking, T-cell activation and cytokine expression.
CAS:
137018-54-3
Formula:
C15H14O4
Molecular Weight:
258.273
Purity:
0.98
SMILES:
Cc1cc(O)cc2cc3C(O)CCC(=O)c3c(O)c12
References
1. Wang XJ, Xiang ZD, Gong DL, Wang JD, Liu CX, Zhu ZX, Yan YJ, Xiang WS. A new okicenone analog from Streptomyces sp. NEAU-W13. J Antibiot (Tokyo). 2011 Jun;64(6):459-60. doi: 10.1038/ja.2011.22. Epub 2011 Mar 30. PubMed PMID: 21448189.
2. Meisner NC, Hintersteiner M, Mueller K, Bauer R, Seifert JM, Naegeli HU, Ottl J, Oberer L, Guenat C, Moss S, Harrer N, Woisetschlaeger M, Buehler C, Uhl V, Auer M. Identification and mechanistic characterization of low-molecular-weight inhibitors for HuR. Nat Chem Biol. 2007 Aug;3(8):508-15. Epub 2007 Jul 15. PubMed PMID: 17632515.
3. Funayama S, Ishibashi M, Komiyama K, Omura S. A new antibiotic, okicenone. II. Physico-chemical properties and structure elucidation. J Antibiot (Tokyo). 1991 Aug;44(8):819-23. PubMed PMID: 1917696.
4. Komiyama K, Funayama S, Anraku Y, Ishibashi M, Takahashi Y, Kawakami T, Omura S. A new antibiotic, okicenone. I. Taxonomy, fermentation, isolation and biological characteristics. J Antibiot (Tokyo). 1991 Aug;44(8):814-8. PubMed PMID: 1917695.