ONO-1714 HCl
| Code | Size | Price |
|---|
| TAR-T28247-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
ONO-1714 is a inducible nitric oxide synthase (NOS-2) inhibitor. ONO-1714 reduces hyperoxic lung injury in mice. ONO-1714 attenuates inflammation-related large bowel carcinogenesis in male Apc(Min/+) mice. ONO-1714 also inhibits neuronal NOS and exerts antinociception in rats.
CAS:
214479-33-1
Formula:
C7H12Cl2N2
Molecular Weight:
195.09
Purity:
0.98
SMILES:
Cl.[H][C@]12NC(=N)C[C@H](C)[C@@]1([H])[C@H]2Cl
References
1. Pozo-Rodrig?lvarez A, Gradillas A, Serrano J, Fern?ndez AP, Mart?nez-Murillo R, P?rez-Castells J. New synthesis and promising neuroprotective role in experimental ischemic stroke of ONO-1714. Eur J Med Chem. 2012 Aug;54:439-46. doi: 10.1016/j.ejmech.2012.05.031. PubMed PMID: 22703704.
2. Mishima T, Tajima Y, Kuroki T, Kosaka T, Adachi T, Kitasato A, Tsuneoka N, Kitajima T, Kanematsu T. Chemopreventative effect of an inducible nitric oxide synthase inhibitor, ONO-1714, on inflammation-associated biliary carcinogenesis in hamsters. Carcinogenesis. 2009 Oct;30(10):1763-7. doi: 10.1093/carcin/bgp194. PubMed PMID: 19696162.
3. Takahashi M, Kitahashi T, Ishigamori R, Mutoh M, Komiya M, Sato H, Kamanaka Y, Naka M, Maruyama T, Sugimura T, Wakabayashi K. Increased expression of inducible nitric oxide synthase (iNOS) in N-nitrosobis(2-oxopropyl)amine-induced hamster pancreatic carcinogenesis and prevention of cancer development by ONO-1714, an iNOS inhibitor. Carcinogenesis. 2008 Aug;29(8):1608-13. doi: 10.1093/carcin/bgn152. PubMed PMID: 18567618.
4. Jiang BH, Maruyama J, Yokochi A, Mitani Y, Maruyama K. A novel inhibitor of inducible nitric oxide synthase, ONO-1714, does not ameliorate hypoxia-induced pulmonary hypertension in rats. Lung. 2007 Sep-Oct;185(5):303-8. PubMed PMID: 17721804.