ONO-8809
| Code | Size | Price |
|---|
| TAR-T28251-5mg | 5mg | £1,653.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T28251-50mg | 50mg | £3,267.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T28251-100mg | 100mg | £4,488.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
ONO-8809 is a thromboxane A2 receptor antagonist. ONO-8809 inhibited the LTC4-induced airway hyperresponsiveness to histamine in a dose-dependent manner. Macrophage accumulation and matrix metalloproteinase-9 (MMP-9) activity in the stroke-negative area in the contralateral cerebral cortex to the stroke lesion of salt-loaded SHRSP and 8-iso-PGF2alpha-treated SHRSP were significantly reduced by ONO-8809 treatment.
CAS:
123288-47-1
Formula:
C30H46BrNO4S
Molecular Weight:
596.67
Purity:
0.98
SMILES:
[H][C@@]12CC[C@@]([H])(C1)[C@@H](C=C/CCCC(=O)OCCCCCCCCCC)[C@@H]2CNS(=O)(=O)c1ccc(Br)cc1
References
1. Ishizuka T, Niwa A, Tabuchi M, Nagatani Y, Ooshima K, Higashino H. Involvement of thromboxane A2 receptor in the cerebrovascular damage of salt-loaded, stroke-prone rats. J Hypertens. 2007 Apr;25(4):861-70. PubMed PMID: 17351380.
2. Kurosawa M, Yodonawa S, Tsukagoshi H. Inhibition of bronchial hyperresponsiveness to histamine induced by intravenous administration of leukotriene C4 by novel thromboxane A2 receptor antagonists ONO-NT-126 and ONO-8809 in guinea-pigs. Clin Exp Allergy. 1993 Oct;23(10):843-50. PubMed PMID: 10780891.
3. Nagata T, Uehara Y, Hara K, Igarashi K, Hazama H, Hisada T, Kimura K, Goto A, Omata M. Thromboxane inhibition and monocrotaline-induced pulmonary hypertension in rats. Respirology. 1997 Dec;2(4):283-9. PubMed PMID: 9525298.
4. Wakitani K, Matsumoto R, Imawaka H, Kamanaka Y, Naka M, Hamanaka N, Okegawa T, Kawasaki A. Anti-thrombotic effect of ONO-8809, a novel TXA2/PG endoperoxide receptor antagonist. Adv Prostaglandin Thromboxane Leukot Res. 1991;21B:599-602. PubMed PMID: 1825384.