Pacidamycin I
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| TAR-T28288-5mg | 5mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Pacidamycin I is an antimicrobial nucleoside antibiotics. Pacidamycin I inhibits translocase I, a key enzyme in peptidoglycan assembly.
CAS:
121264-05-9
Formula:
C41H50N10O12
Molecular Weight:
874.909
Purity:
0.98
SMILES:
C[C@H](N)C(=O)N[C@@H](Cc1cccc(O)c1)C(=O)N(C)C(C)C(N)C(=O)N(C=C1/CC(O)C(O1)n1ccc(=O)[nH]c1=O)C(=O)[C@H](C)NC(=O)NC(Cc1c[nH]c2ccccc12)C(O)=O
References
1. Okamoto K, Sakagami M, Feng F, Togame H, Takemoto H, Ichikawa S, Matsuda A. Total synthesis of pacidamycin D by Cu(I)-catalyzed oxy enamide formation. Org Lett. 2011 Oct 7;13(19):5240-3. doi: 10.1021/ol202124b. Epub 2011 Sep 8. PubMed PMID: 21902200.
2. Ragab AE, Gr?schow S, Tromans DR, Goss RJ. Biogenesis of the unique 4',5'-dehydronucleoside of the uridyl peptide antibiotic pacidamycin. J Am Chem Soc. 2011 Oct 5;133(39):15288-91. doi: 10.1021/ja206163j. Epub 2011 Sep 12. PubMed PMID: 21861518.
3. Tromans DR, Stevenson CE, Goss RJ, Lawson DM. Crystallization and preliminary X-ray analysis of Pac17 from the pacidamycin-biosynthetic cluster of Streptomyces coeruleorubidus. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Aug 1;68(Pt 8):971-4. doi: 10.1107/S1744309112029144. Epub 2012 Jul 31. PubMed PMID: 22869135; PubMed Central PMCID: PMC3412786.
4. Boojamra CG, Lemoine RC, Lee JC, L?ger R, Stein KA, Vernier NG, Magon A, Lomovskaya O, Martin PK, Chamberland S, Lee MD, Hecker SJ, Lee VJ. Stereochemical elucidation and total synthesis of dihydropacidamycin D, a semisynthetic pacidamycin. J Am Chem Soc. 2001 Feb 7;123(5):870-4. PubMed PMID: 11456620.