PF-1163B
| Code | Size | Price |
|---|
| TAR-T28379-5mg | 5mg | £2,003.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
PF-1163B is an antifungal agent form Penicillium sp. II. PF-1163B inhibits ergosterol (ERG) synthesis with IC50 value of 34 ng/ml. PF-1163B showed potent growth inhibitory activity against pathogenic fungal strain Candida albicans but did not show cytotoxic activity against mammalian cells.
CAS:
258871-60-2
Formula:
C27H43NO5
Molecular Weight:
461.643
Purity:
0.98
SMILES:
CCCCC[C@@H]1CC[C@H](C)CCCCC(=O)N(C)[C@@H](Cc2ccc(OCCO)cc2)C(=O)O1
References
1. Bouazza F, Renoux B, Bachmann C, Gesson JP. Total synthesis and conformational analysis of the antifungal agent (-)-PF1163B. Org Lett. 2003 Oct 30;5(22):4049-52. Erratum in: Org Lett. 2004 Mar 18;6(6):1069. PubMed PMID: 14572246.
2. Sasaki T, Nose H, Hosoya A, Yoshida S, Kawaguchi M, Watanabe T, Usui T, Ohtsuka Y, Shomura T, Takano S, Tatsuta K. PF1163A and B, new antifungal antibiotics produced by Penicillium sp. II. Physico-chemical properties and structure elucidation. J Antibiot (Tokyo). 2000 Jan;53(1):38-44. PubMed PMID: 10724006.
3. Nose H, Seki A, Yaguchi T, Hosoya A, Sasaki T, Hoshiko S, Shomura T. PF1163A and B, new antifungal antibiotics produced by Penicillium sp. I. Taxonomy of producing strain, fermentation, isolation and biological activities. J Antibiot (Tokyo). 2000 Jan;53(1):33-7. PubMed PMID: 10724005.
4. Tatsuta K, Takano S, Ikeda Y, Nakano S, Miyazaki S. The total synthesis and absolute structure of antifungal antibiotics(-)-PF1163A and B. J Antibiot (Tokyo). 1999 Dec;52(12):1146-51. PubMed PMID: 10695680.