PGP-4008
| Code | Size | Price |
|---|
| TAR-T28396-5mg | 5mg | £791.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T28396-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T28396-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
PGP-4008 is a selective inhibitor of P-glycoprotein (P-gp). PGP-4008 shows the inhibition effect of tumor growth in combination with doxorubicin.
CAS:
365565-02-2
Formula:
C26H23N3O
Molecular Weight:
393.49
Purity:
0.98
SMILES:
O=C(Cc1ccccc1)Nc1c2CCN(Cc3ccccc3)c2nc2ccccc12
References
1. Huang L, Wang J, Chen WC, Li HY, Liu JS, Tao Jiang, Yang WD. P-glycoprotein expression in Perna viridis after exposure to Prorocentrum lima, a dinoflagellate producing DSP toxins. Fish Shellfish Immunol. 2014 Aug;39(2):254-62. doi: 10.1016/j.fsi.2014.04.020. PubMed PMID: 24811006.
2. Yoshino Y, Yuan B, Kaise T, Takeichi M, Tanaka S, Hirano T, Kroetz DL, Toyoda H. Contribution of aquaporin 9 and multidrug resistance-associated protein 2 to differential sensitivity to arsenite between primary cultured chorion and amnion cells prepared from human fetal membranes. Toxicol Appl Pharmacol. 2011 Dec 1;257(2):198-208. doi: 10.1016/j.taap.2011.09.006. PubMed PMID: 21945491; PubMed Central PMCID: PMC3470788.
3. Miettinen S, Gr?nman S, Ylikomi T. Inhibition of P-glycoprotein-mediated docetaxel efflux sensitizes ovarian cancer cells to concomitant docetaxel and SN-38 exposure. Anticancer Drugs. 2009 Apr;20(4):267-76. doi: 10.1097/CAD.0b013e328329977f. PubMed PMID: 19262372.
4. Karla PK, Earla R, Boddu SH, Johnston TP, Pal D, Mitra A. Molecular expression and functional evidence of a drug efflux pump (BCRP) in human corneal epithelial cells. Curr Eye Res. 2009 Jan;34(1):1-9. doi: 10.1080/02713680802518251. PubMed PMID: 19172464; PubMed Central PMCID: PMC4406241.