Phenoprolamine Hydrochloride
| Code | Size | Price |
|---|
| TAR-T28400-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T28400-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T28400-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Phenoprolamine Hydrochloride is an adrenergic α1 receptor antagonist with potent antihypertensive, neuroprotective and cardioprotective effects. Phenoprolamine Hydrochloride inhibits CYP2D and CYP3A activities and down-regulates their mRNA transcription and protein expression. Phenoprolamine Hydrochloride can efficiently penetrate through blood brain barrier and inhibit the contraction of vascular smooth muscle in the brain.
CAS:
93933-71-2
Formula:
C21H30ClNO3
Molecular Weight:
379.93
Purity:
0.98
SMILES:
Cl.COc1ccc(CCNC(C)COc2c(C)cccc2C)cc1OC
References
1. Zhao L, Hu J, Chang Q, Ke Q, Xu R, Gu S, Chen H, Zeng F. A simple and sensitive HPLC method for quantitation of low phenoprolamine hydrochloride concentrations in human plasma and its pharmacokinetic application. Biomed Chromatogr. 2008 Mar;22(3):333-8. PubMed PMID: 18059052.
2. Zhao L, Yang X, Xu R, Wu J, Gu S, Zhang L, Gong P, Chen H, Zeng F. Safety, tolerability and pharmacokinetics of phenoprolamine hydrochloride floating sustained-release tablets in healthy Chinese subjects. Int J Pharm. 2009 Jul 30;377(1-2):99-104. doi: 10.1016/j.ijpharm.2009.05.010. PubMed PMID: 19446622.
3. Ding L, Zhang ZX, Ni PZ, Wang GJ, An DK. [Study on the phase II metabolites of phenoprolamine hydrochloride in rat bile by LC/DAD/MSD]. Yao Xue Xue Bao. 2001 Jun;36(6):440-3. Chinese. PubMed PMID: 12585129.
4. Ding L, Zhang ZX, Ni PZ, Wang GJ, An DK. [Study on the phase I metabolites of phenoprolamine hydrochloride in rat bile by LC/DAD/MSD]. Yao Xue Xue Bao. 2001 Mar;36(3):205-9. Chinese. PubMed PMID: 12580089.