PI-091
| Code | Size | Price |
|---|
| TAR-T28412-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
PI-091 inhibits platelet aggregation.
CAS:
129051-63-4
Formula:
C17H29NO4
Molecular Weight:
311.422
Purity:
0.98
SMILES:
CCCCCC[C@](C)(O)C(=O)C1=C[C@](NC1=O)(OC)C(C)C
References
1. Uchiro H, Shionozaki N, Kobayakawa Y, Nakagawa H, Makino K. A novel convergent method for the synthesis of ?-acyl-?-hydroxylactams and its application in the total synthesis of PI-090 and 091. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4765-8. doi: 10.1016/j.bmcl.2012.05.065. Epub 2012 May 24. PubMed PMID: 22704239.
2. Clark AJ, Dell CP, McDonagh JM, Geden J, Mawdsley P. Oxidative 5-endo cyclization of enamides mediated by ceric ammonium nitrate. Org Lett. 2003 Jun 12;5(12):2063-6. PubMed PMID: 12790529.
3. Iwasawa N, Maeyama K. A Highly Efficient Synthesis of (-)-PI-091 Construction of the 4-Alkoxy-2-butene-4-lactam Skeleton from Fischer-Type Carbene Complexes, Alkynyllithiums, and Tosyl Isocyanate. J Org Chem. 1997 Apr 4;62(7):1918-1919. PubMed PMID: 11671489.
4. Shiraki R, Sumino A, Tadano Ki KI, Ogawa S. Total Synthesis of Natural PI-091, a New Platelet Aggregation Inhibitor of Microbial Origin. J Org Chem. 1996 Apr 19;61(8):2845-2852. PubMed PMID: 11667121.