PM-060184
| Code | Size | Price |
|---|
| TAR-T28428-5mg | 5mg | £2,858.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T28428-50mg | 50mg | £5,677.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T28428-100mg | 100mg | £8,103.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
PM-060184, a tubulin polymerisation inhibitor, is used potentially for the treatment of solid tumours and breast cancer.
CAS:
960210-99-5
Formula:
C31H45N3O7
Molecular Weight:
571.715
Purity:
0.98
SMILES:
COC1=CC[C@H](OC1=O)[C@@H](C)C=C(/C)C=C/C=CC(=O)N[C@H](C(=O)NC=C/C[C@H](CC=C/C)OC(N)=O)C(C)(C)C
References
1. Mart?nez-D?ez M, Guill?n-Navarro MJ, Pera B, Bouchet BP, Mart?nez-Leal JF, Barasoain I, Cuevas C, Andreu JM, Garc?a-Fern?ndez LF, D?az JF, Avil?s P, Galmarini CM. PM060184, a new tubulin binding agent with potent antitumor activity including P-glycoprotein over-expressing tumors. Biochem Pharmacol. 2014 Apr 1;88(3):291-302. doi: 10.1016/j.bcp.2014.01.026. PubMed PMID: 24486569.
2. Pera B, Barasoain I, Pantazopoulou A, Canales A, Matesanz R, Rodriguez-Salarichs J, Garc?a-Fernandez LF, Moneo V, Jim?nez-Barbero J, Galmarini CM, Cuevas C, Pe?alva MA, D?az JF, Andreu JM. New interfacial microtubule inhibitors of marine origin, PM050489/PM060184, with potent antitumor activity and a distinct mechanism. ACS Chem Biol. 2013 Sep 20;8(9):2084-94. doi: 10.1021/cb400461j. PubMed PMID: 23859655.
3. Mart?n MJ, Coello L, Fern?ndez R, Reyes F, Rodr?guez A, Murcia C, Garranzo M, Mateo C, S?nchez-Sancho F, Bueno S, de Eguilior C, Francesch A, Munt S, Cuevas C. Isolation and first total synthesis of PM050489 and PM060184, two new marine anticancer compounds. J Am Chem Soc. 2013 Jul 10;135(27):10164-71. doi: 10.1021/ja404578u. PubMed PMID: 23750450.
4. Prota AE, Bargsten K, Diaz JF, Marsh M, Cuevas C, Liniger M, Neuhaus C, Andreu JM, Altmann KH, Steinmetz MO. A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs. Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13817-21. doi: 10.1073/pnas.1408124111. PubMed PMID: 25114240; PubMed Central PMCID: PMC4183314.