PNU-142721
| Code | Size | Price |
|---|
| TAR-T28432-5mg | 5mg | £1,332.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T28432-50mg | 50mg | £2,625.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T28432-100mg | 100mg | £3,524.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
PNU-142721, reverse transcriptase inhibitor, is used to treat human immunodeficiency virus (HIV) infection.
CAS:
185220-03-5
Formula:
C13H11ClN4OS
Molecular Weight:
306.77
Purity:
0.98
SMILES:
C[C@H](Sc1nc(N)cc(Cl)n1)c1cc2ccoc2cn1
References
1. Chen KB, Chen HY, Chen KC, Chen CY. Treatment of cardiovascular disease by traditional Chinese medicine against pregnane X receptor. Biomed Res Int. 2014;2014:950191. doi: 10.1155/2014/950191. Epub 2014 Jun 22. PubMed PMID: 25050380; PubMed Central PMCID: PMC4090537.
2. Pal M, Srivastava G, Moon LS, Jolly RS. Bioreduction of methyl heteroaryl and aryl heteroaryl ketones in high enantiomeric excess with newly isolated fungal strains. Bioresour Technol. 2012 Aug;118:306-14. doi: 10.1016/j.biortech.2012.05.031. Epub 2012 May 17. PubMed PMID: 22705956.
3. Cheng Y, Redinbo MR. Activation of the human nuclear xenobiotic receptor PXR by the reverse transcriptase-targeted anti-HIV drug PNU-142721. Protein Sci. 2011 Oct;20(10):1713-9. doi: 10.1002/pro.706. Epub 2011 Sep 12. PubMed PMID: 21805522; PubMed Central PMCID: PMC3218365.
4. Lindberg J, Sigurdsson S, L?wgren S, Andersson HO, Sahlberg C, Nor?en R, Fridborg K, Zhang H, Unge T. Structural basis for the inhibitory efficacy of efavirenz (DMP-266), MSC194 and PNU142721 towards the HIV-1 RT K103N mutant. Eur J Biochem. 2002 Mar;269(6):1670-7. PubMed PMID: 11895437.