Polyoxin B
| Code | Size | Price |
|---|
| TAR-T28436-5mg | 5mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Polyoxin B is a nucleoside antibiotics composed of heterocyclic moieties containing nitrogen. Polyoxin B inhibits the biosynthesis of chitin.
CAS:
19396-06-6
Formula:
C17H25N5O13
Molecular Weight:
507.409
Purity:
0.98
SMILES:
N[C@@H]([C@H](O)[C@@H](O)COC(N)=O)C(=O)N[C@@H]([C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(CO)c(=O)[nH]c1=O)C(O)=O
References
1. Ji Q, Ge Z, Ge Z, Chen K, Wu H, Liu X, Huang Y, Yuan L, Yang X, Liao F. Synthesis and biological evaluation of novel phosphoramidate derivatives of coumarin as chitin synthase inhibitors and antifungal agents. Eur J Med Chem. 2016 Jan 27;108:166-176. doi: 10.1016/j.ejmech.2015.11.027. Epub 2015 Nov 23. PubMed PMID: 26647304.
2. Ji Q, Yang D, Wang X, Chen C, Deng Q, Ge Z, Yuan L, Yang X, Liao F. Design, synthesis and evaluation of novel quinazoline-2,4-dione derivatives as chitin synthase inhibitors and antifungal agents. Bioorg Med Chem. 2014 Jul 1;22(13):3405-13. doi: 10.1016/j.bmc.2014.04.042. Epub 2014 Apr 30. PubMed PMID: 24856180.
3. Yoon MY, Choi NH, Min BS, Choi GJ, Choi YH, Jang KS, Han SS, Cha B, Kim JC. Potent in vivo antifungal activity against powdery mildews of pregnane glycosides from the roots of Cynanchum wilfordii. J Agric Food Chem. 2011 Nov 23;59(22):12210-6. doi: 10.1021/jf2039185. Epub 2011 Oct 20. PubMed PMID: 21992072.
4. Li J, Li L, Tian Y, Niu G, Tan H. Hybrid antibiotics with the nikkomycin nucleoside and polyoxin peptidyl moieties. Metab Eng. 2011 May;13(3):336-44. doi: 10.1016/j.ymben.2011.01.002. Epub 2011 Feb 1. PubMed PMID: 21292022.