R-(-)-Niguldipine hydrochloride
| Code | Size | Price |
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| TAR-T28489-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
R-(-)-Niguldipine hydrochloride is a L-type Ca2+ channel blocker; potassium agonist that activates Ca2+-activated maxi K-channel; alpha1A-adrenoceptor antagonist; antihypertensive agent; Less active enantiomer.
CAS:
113145-70-3
Formula:
C36H40ClN3O6
Molecular Weight:
646.18
Purity:
0.98
SMILES:
Cl.COC(=O)C1=C(C)NC(C)=C([C@@H]1c1cccc(c1)[N+]([O-])=O)C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1
References
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2. Honner V, Docherty JR. Investigation of the subtypes of alpha1-adrenoceptor mediating contractions of rat vas deferens. Br J Pharmacol. 1999 Nov;128(6):1323-31. PubMed PMID: 10578148; PubMed Central PMCID: PMC1571755.
3. Macleod RJ, Lembessis P, James S, Bennett HP. Isolation of a member of the neurotoxin/cytotoxin peptide family from Xenopus laevis skin which activates dihydropyridine-sensitive Ca2+ channels in mammalian epithelial cells. J Biol Chem. 1998 Aug 7;273(32):20046-51. PubMed PMID: 9685343.
4. Taniguchi N, Ukai Y, Tanaka T, Yano J, Kimura K, Moriyama N, Kawabe K. Identification of alpha 1-adrenoceptor subtypes in the human prostatic urethra. Naunyn Schmiedebergs Arch Pharmacol. 1997 Mar;355(3):412-6. PubMed PMID: 9089674.