Ro 18-5364
| Code | Size | Price |
|---|
| TAR-T28563-5mg | 5mg | £1,010.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T28563-50mg | 50mg | £1,982.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T28563-100mg | 100mg | £2,560.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Ro 18-5364 is a potent inhibitor of the gastric (H+ + K+)-ATPase with an apparent Ki of 0.1 μM at pH 6.
CAS:
101387-98-8
Formula:
C22H25N3O3S
Molecular Weight:
411.52
Purity:
0.98
SMILES:
COc1ccnc(CS(=O)c2nc3cc4c(cc3[nH]2)C(C)(C)C(=O)C4(C)C)c1C
References
1. Belaz KR, Coimbra M, Barreiro JC, Montanari CA, Cass QB. Multimilligram enantioresolution of sulfoxide proton pump inhibitors by liquid chromatography on polysaccharide-based chiral stationary phase. J Pharm Biomed Anal. 2008 May 12;47(1):81-7. doi: 10.1016/j.jpba.2007.12.018. PubMed PMID: 18242919.
2. Bastaki SM, Chandranath I, Garner A. Comparison of five antisecretory agents acting via gastric H+/K+-ATPase. J Physiol Paris. 2000 Jan-Feb;94(1):19-23. PubMed PMID: 10761684.
3. Guinotte F, Gautron J, Soumarmon A, Robert JC, Peranzi G, Nys Y. Gastric acid secretion in the chicken: effect of histamine H2 antagonists and H+/K(+)-ATPase inhibitors on gastro-intestinal pH and of sexual maturity calcium carbonate level and particle size on proventricular H+/K+ ATPase activity. Comp Biochem Physiol Comp Physiol. 1993 Oct;106(2):319-27. PubMed PMID: 7902802.
4. Morii M, Takata H, Fujisaki H, Takeguchi N. The potency of substituted benzimidazoles such as E3810, omeprazole, Ro 18-5364 to inhibit gastric H+, K(+)-ATPase is correlatedwith the rate of acid-activation of the inhibitor. Biochem Pharmacol. 1990 Feb 15;39(4):661-7. PubMed PMID: 2154989.