Ro 24-5098
| Code | Size | Price |
|---|
| TAR-T28575-5mg | 5mg | £1,091.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T28575-50mg | 50mg | £2,143.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T28575-100mg | 100mg | £2,801.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Ro 24-5098 is an anti-HIV inhibitory effects of isoddA pronucleotides.
CAS:
127682-75-1
Formula:
C10H13N5O2
Molecular Weight:
235.247
Purity:
0.98
SMILES:
Nc1ncnc2n(cnc12)[C@H]1CO[C@@H](CO)C1
References
1. Pal S, Nair V. Phosphorylation of the anti-HIV compound (S,S)-isodideoxyadenosine by human recombinant deoxycytidine kinase. Biochem Pharmacol. 2000 Nov 15;60(10):1505-8. PubMed PMID: 11020453.
2. Valette G, Pompon A, Girardet JL, Cappellacci L, Franchetti P, Grifantini M, La Colla P, Loi AG, P?rigaud C, Gosselin G, Imbach JL. Decomposition pathways and in vitro HIV inhibitory effects of isoddA pronucleotides: toward a rational approach for intracellular delivery of nucleoside 5'-monophosphates. J Med Chem. 1996 May 10;39(10):1981-90. PubMed PMID: 8642557.
3. Nair V, St Clair MH, Reardon JE, Krasny HC, Hazen RJ, Paff MT, Boone LR, Tisdale M, Najera I, Dornsife RE, et al. Antiviral, metabolic, and pharmacokinetic properties of the isomeric dideoxynucleoside
4(S)-(6-amino-9H-purin-9-yl)tetrahydro-2(S)-furanmethanol. Antimicrob Agents Chemother. 1995 Sep;39(9):1993-9. PubMed PMID: 8540705; PubMed Central PMCID: PMC162870. 4. Franchetti P, Cappellacci L, Grifantini M, Messini L, abu Sheikha G, Loi AG, Tramontano E, de Montis A, Spiga MG, La Colla P. Synthesis and evaluation of the anti-HIV activity of aza and deaza analogues of isoddA and their phosphates as prodrugs. J Med Chem. 1994 Oct 14;37(21):3534-41. PubMed PMID: 7523675.
4(S)-(6-amino-9H-purin-9-yl)tetrahydro-2(S)-furanmethanol. Antimicrob Agents Chemother. 1995 Sep;39(9):1993-9. PubMed PMID: 8540705; PubMed Central PMCID: PMC162870. 4. Franchetti P, Cappellacci L, Grifantini M, Messini L, abu Sheikha G, Loi AG, Tramontano E, de Montis A, Spiga MG, La Colla P. Synthesis and evaluation of the anti-HIV activity of aza and deaza analogues of isoddA and their phosphates as prodrugs. J Med Chem. 1994 Oct 14;37(21):3534-41. PubMed PMID: 7523675.