Ro-23-9424
| Code | Size | Price |
|---|
| TAR-T28598-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Ro-23-9424 is a dual-action cephalosporin with a fleroxacin esterified at the 3' position and aminothiazolylmethoxyimino-type side chain at the 7 position. Ro-23-9424 has broad and potent antibacterial activity in vitro and in vivo.
CAS:
115622-58-7
Formula:
C31H31F3N8O8S2
Molecular Weight:
764.75
Purity:
0.98
SMILES:
CON=C(/C(=O)N[C@H]1[C@H]2SCC(COC(=O)c3cn(CCF)c4c(F)c(N5CCN(C)CC5)c(F)cc4c3=O)=C(N2C1=O)C(O)=O)c1csc(N)n1
References
1. Matera G, Berlinghieri MC, Foti F, Barreca GS, Foc? A. Effect of RO 23-9424, cefotaxime and fleroxacin on functions of human polymorphonuclear cells and cytokine production by human monocytes. J Antimicrob Chemother. 1996 Nov;38(5):799-807. PubMed PMID: 8961049.
2. Chapman JS, Bertasso A, Cummings LM, Georgopapadakou NH. Low-level resistance to the cephalosporin 3'-quinolone ester Ro 23-9424 in Escherichia coli. Antimicrob Agents Chemother. 1995 Feb;39(2):564-6. PubMed PMID: 7726536; PubMed Central PMCID: PMC162583.
3. Qadri SM, Ueno Y, Ayub A. Anti-Brucella activity of Ro 23-9424, a dual-action antibacterial. Chemotherapy. 1993 Nov-Dec;39(6):386-9. PubMed PMID: 8222864.
4. Szuna AJ, Blain RW. Determination of a new antibacterial agent (Ro 23-9424) by multidimensional high-performance liquid chromatography with ultraviolet detection and direct plasma injection. J Chromatogr. 1993 Oct 29;620(2):211-6. PubMed PMID: 8300788.