Rohitukine
| Code | Size | Price |
|---|
| TAR-T28609-5mg | 5mg | £1,010.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T28609-50mg | 50mg | £1,982.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T28609-100mg | 100mg | £2,560.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Rohitukine is an anti-cancer agent. It modulates apoptosis pathways through gastrin antagonism and H(+) K (+)-ATPase inhibition. Rohitukine ia an antiadipogenic, antidyslipidemic, gastroprotective, antifertility, and antileishmanial compound.
CAS:
71294-60-5
Formula:
C16H19NO5
Molecular Weight:
305.33
Purity:
0.98
SMILES:
CN1CC[C@H]([C@@H](O)C1)c1c(O)cc(O)c2c1oc(C)cc2=O
References
1. Amin SA, Bhattacharya P, Basak S, Gayen S, Nandy A, Saha A. Pharmacoinformatics study of Piperolactam A from Piper betle root as new lead for non steroidal anti fertility drug development. Comput Biol Chem. 2017 Apr;67:213-224. doi: 10.1016/j.compbiolchem.2017.01.004. Epub 2017 Jan 11. PubMed PMID: 28160639.
2. Isah T. Anticancer Alkaloids from Trees: Development into Drugs. Pharmacogn Rev. 2016 Jul-Dec;10(20):90-99. doi: 10.4103/0973-7847.194047. Review. PubMed PMID: 28082790; PubMed Central PMCID: PMC5214563.
3. Kumar V, Bharate SS, Vishwakarma RA. Modulating lipophilicity of rohitukine via prodrug approach: Preparation, characterization, and in vitro enzymatic hydrolysis in biorelevant media. Eur J Pharm Sci. 2016 Sep 20;92:203-11. doi: 10.1016/j.ejps.2016.07.010. Epub 2016 Jul 12. PubMed PMID: 27422078.
4. Kumar V, Guru SK, Jain SK, Joshi P, Gandhi SG, Bharate SB, Bhushan S, Bharate SS, Vishwakarma RA. A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3457-63. doi: 10.1016/j.bmcl.2016.06.046. Epub 2016 Jun 16. PubMed PMID: 27363938.