RSD-921
| Code | Size | Price |
|---|
| TAR-T28619-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T28619-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T28619-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
RSD-921 is sodium channel antagonist. RSD 921 produces similarly potent tonic block of all three wild-type channel isoforms with EC50 values between 35 and 47 microM, whereas the EC50 for block of the IFMQ3 mutant channel is 110+5.5 microM.
CAS:
114419-77-1
Formula:
C21H28N2OS
Molecular Weight:
356.52
Purity:
0.98
SMILES:
CN([C@@H]1CCCC[C@H]1N1CCCC1)C(=O)Cc1cccc2sccc12
References
1. Pugsley MK, Saint DA, Hayes ES, Abraham S, Walker MJ. An examination of the cardiac actions of PD117,302, a ?-opioid receptor agonist. Eur J Pharmacol. 2015 Aug 15;761:330-40. doi: 10.1016/j.ejphar.2015.06.018. PubMed PMID: 26086860.
2. Gullapalli S, Ramarao P. L-type Ca2+ channel modulation by dihydropyridines potentiates kappa-opioid receptor agonist induced acute analgesia and inhibits development of tolerance in rats. Neuropharmacology. 2002 Mar;42(4):467-75. PubMed PMID: 11955518.
3. Ribeiro W, Ifa DR, Corso G, Salmon J, Moraes LA, Eberlin MN, de Nucci G. Determination of RSD921 in human plasma by high-performance liquid chromatography-tandem mass spectrometry using tri-deuterated RSD921 as internal standard: application to a phase I clinical trial. J Mass Spectrom. 2001 Oct;36(10):1133-9. PubMed PMID: 11747107.
4. Nemmani KV, Gullapalli S, Ramarao P. Potentiation of kappa-opioid receptor agonist-induced analgesia and hypothermia by fluoxetine. Pharmacol Biochem Behav. 2001 May-Jun;69(1-2):189-93. PubMed PMID: 11420085.