TargetMol

SCH-900229

Product Code:
 
TAR-T28735
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28735-5mg5mg£1,653.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T28735-50mg50mg£3,267.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T28735-100mg100mg£4,488.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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  • Further Information
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Further Information

Bioactivity:
SCH-900229, a potent presenilin 1 selective γ-secretase inhibitor, used to treat Alzheimer?s Disease.
CAS:
1100361-36-1
Formula:
C21H21ClF2O6S2
Molecular Weight:
506.96
Purity:
0.98
SMILES:
[H][C@@]12COc3c(F)ccc(F)c3[C@@]1(CCO[C@H]2CCS(C)(=O)=O)S(=O)(=O)c1ccc(Cl)cc1

References

1. Wu WL, Burnett DA, Clader J, Greenlee WJ, Jiang Q, Hyde LA, Del Vecchio RA, Cohen-Williams ME, Song L, Lee J, Terracina G, Zhang Q, Nomeir A, Parker EM, Zhang L. Design and synthesis of water soluble ?-aminosulfone analogues of SCH 900229 as ?-secretase inhibitors. Bioorg Med Chem Lett. 2016 Dec 1;26(23):5836-5841. doi: 10.1016/j.bmcl.2016.04.095. Epub 2016 May 7. PubMed PMID: 27836402. 2. Wu WL, Sasikumar TK, Domalski MS, Qiang L, Burnett DA, Clader J, Greenlee WJ, Chan TM, Lee J, Zhang L. A-ring modification of SCH 900229 and related chromene sulfone ?-secretase inhibitors. Bioorg Med Chem Lett. 2013 Feb 1;23(3):850-3. doi: 10.1016/j.bmcl.2012.11.054. Epub 2012 Nov 28. PubMed PMID: 23265902. 3. Wu WL, Asberom T, Bara T, Bennett C, Burnett DA, Clader J, Domalski M, Greenlee WJ, Josien H, McBriar M, Rajagopalan M, Vicarel M, Xu R, Hyde LA, Del Vecchio RA, Cohen-Williams ME, Song L, Lee J, Terracina G, Zhang Q, Nomeir A, Parker EM, Zhang L. Structure activity relationship studies of tricyclic bispyran sulfone ?-secretase inhibitors. Bioorg Med Chem Lett. 2013 Feb 1;23(3):844-9. doi: 10.1016/j.bmcl.2012.11.047. Epub 2012 Nov 24. PubMed PMID: 23265892. 4. Wu WL, Domalski M, Burnett DA, Josien H, Bara T, Rajagopalan M, Xu R, Clader J, Greenlee WJ, Brunskill A, Hyde LA, Del Vecchio RA, Cohen-Williams ME, Song L, Lee J, Terracina G, Zhang Q, Nomeir A, Parker EM, Zhang L. Discovery of SCH 900229, a Potent Presenilin 1 Selective ?-Secretase Inhibitor for the Treatment of Alzheimer's Disease. ACS Med Chem Lett. 2012 Apr 9;3(11):892-6. doi: 10.1021/ml300044f. eCollection 2012 Nov 8. PubMed PMID: 24900404; PubMed Central PMCID: PMC4025742.