Showdomycin
| Code | Size | Price |
|---|
| TAR-T28771-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Showdomycin is an antibiotic with antineoplastic activity.
CAS:
16755-07-0
Formula:
C9H11NO6
Molecular Weight:
229.188
Purity:
0.98
SMILES:
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)C1=CC(=O)NC1=O
References
1. Palmu K, Rosenqvist P, Thapa K, Ilina Y, Siitonen V, Baral B, M?kinen J, Belogurov G, Virta P, Niemi J, Mets?-Ketel? M. Discovery of the Showdomycin Gene Cluster from Streptomyces showdoensis ATCC 15227 Yields Insight into the Biosynthetic Logic of C-Nucleoside Antibiotics. ACS Chem Biol. 2017 Apr 27. doi: 10.1021/acschembio.7b00078. [Epub ahead of print] PubMed PMID: 28418235.
2. De Clercq E. C-Nucleosides To Be Revisited. J Med Chem. 2016 Mar 24;59(6):2301-11. doi: 10.1021/acs.jmedchem.5b01157. Epub 2015 Oct 29. Review. PubMed PMID: 26513594.
3. Rudolf GC, Koch MF, Mandl FA, Sieber SA. Subclass-specific labeling of protein-reactive natural products with customized nucleophilic probes. Chemistry. 2015 Feb 23;21(9):3701-7. doi: 10.1002/chem.201405009. Epub 2015 Jan 21. PubMed PMID: 25605563.
4. B?ttcher T, Sieber SA. Showdomycin as a versatile chemical tool for the detection of pathogenesis-associated enzymes in bacteria. J Am Chem Soc. 2010 May 26;132(20):6964-72. doi: 10.1021/ja909150y. PubMed PMID: 20433172.