SHR-110008
| Code | Size | Price |
|---|
| TAR-T28772-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
SHR-110008, a microtubule inhibitor, is used potentially for the treatment of cancer.
CAS:
944154-59-0
Formula:
C50H64N2O15
Molecular Weight:
933.061
Purity:
0.98
SMILES:
CC(=O)O[C@@]12COC1CC(O)[C@@]1(C)C3OC(CN4CC5CC4CO5)OC3C3=C(C)C(C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@H]21)C3(C)C)OC(=O)C(O)C(NC(=O)OC(C)(C)C)c1ccccc1
References
1. Ding Y, Liu W, Lu C, Yang J, Zhu Y, Song Y, Ma Z, Yang L, Jia Y, Wen A. Preclinical pharmacokinetic analysis of felotaxel (SHR110008), a novel derivative of docetaxel, in rats and its protein binding ability in vitro. Biomed Pharmacother. 2012 Mar;66(2):98-102. doi: 10.1016/j.biopha.2011.11.012. PubMed PMID: 22264880.
2. Ding Y, Jia Y, Lu C, Liu W, Yang J, Song Y, Zhu Y, Yang L, Ding L, Wen A. In vitro assessment of cytochrome P450 inhibition and induction potential of felotaxel (SHR110008). Biomed Pharmacother. 2012 Jun;66(4):318-21. doi: 10.1016/j.biopha.2012.01.001. PubMed PMID: 22397757.
3. Ding Y, Lu C, Yang J, Jin X, Yang L, Wang C, Ma Z, Zhu Y, Ding L, Jia Y, Wen A. Application of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to the pharmacokinetics, tissue distribution and excretion studies of felotaxel (SHR110008) in tumor-bearing mice. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Mar 1;887-888:61-6. doi: 10.1016/j.jchromb.2012.01.010. PubMed PMID: 22309773.
4. Yan L, YanYan J, MinChun C, Jing Y, Ying S, ChengTao L, Jie G, CaiYang L, ZhenXing Z, AiDong W, Yi D. High-performance liquid chromatographic analysis of felotaxel, a novel anti-cancer drug, in rat plasma and in human plasma and urine. J Chromatogr Sci. 2013 Mar;51(3):292-6. doi: 10.1093/chromsci/bms140. PubMed PMID: 22933511.