SNAP-7941
| Code | Size | Price |
|---|
| TAR-T28823-5mg | 5mg | £1,332.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T28823-50mg | 50mg | £2,625.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T28823-100mg | 100mg | £3,524.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
SNAP-7941 is a selective antagonist of the melanin concentrating hormone receptor MCH1 with promising anxiolytic, antidepressant and anorectic effects in initial animal studies.
CAS:
387825-78-7
Formula:
C31H37F2N5O6
Molecular Weight:
613.663
Purity:
0.98
SMILES:
COCC1=C([C@@H](N(C(=O)NCCCN2CCC(CC2)c2cccc(NC(C)=O)c2)C(=O)N1)c1ccc(F)c(F)c1)C(=O)OC
References
1. Schirmer E, Shanab K, Datterl B, Neudorfer C, Mitterhauser M, Wadsak W, Philippe C, Spreitzer H. Syntheses of precursors and reference compounds of the melanin-concentrating hormone receptor 1 (MCHR1) tracers [??C]SNAP-7941 and [??F]FE@SNAP for positron emission tomography. Molecules. 2013 Sep 30;18(10):12119-43. doi: 10.3390/molecules181012119. PubMed PMID: 24084017.
2. Philippe C, Nics L, Zeilinger M, Kuntner C, Wanek T, Mairinger S, Shanab K, Spreitzer H, Viernstein H, Wadsak W, Mitterhauser M. Preclinical in vitro &in vivo evaluation of [(11)C]SNAP-7941 - the first PET tracer for the melanin concentrating hormone receptor 1. Nucl Med Biol. 2013 Oct;40(7):919-25. doi: 10.1016/j.nucmedbio.2013.05.010. Epub 2013 Jul 3. PubMed PMID: 23829932.
3. Philippe C, Schirmer E, Mitterhauser M, Shanab K, Lanzenberger R, Karanikas G, Spreitzer H, Viernstein H, Wadsak W. Radiosynthesis of [11C]SNAP-7941--the first PET-tracer for the melanin concentrating hormone receptor 1 (MCHR1). Appl Radiat Isot. 2012 Oct;70(10):2287-94. doi: 10.1016/j.apradiso.2012.07.010. Epub 2012 Jul 20. PubMed PMID: 22858577; PubMed Central PMCID: PMC3439630.
4. Goss JM, Schaus SE. Enantioselective synthesis of SNAP-7941: chiral dihydropyrimidone inhibitor of MCH1-R. J Org Chem. 2008 Oct 3;73(19):7651-6. doi: 10.1021/jo801463j. Epub 2008 Sep 4. PubMed PMID: 18767801; PubMed Central PMCID: PMC2666257.