SR57227A
| Code | Size | Price |
|---|
| TAR-T28850-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T28850-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T28850-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
SR 57227A is a highly selective of peripheral and central 5-HT3 receptors and an inhibitor of NMDA receptor-mediated responses in rat cortical pyramidal cells. It exhibits anti-depressant like effects in rats and decreased isolation-induced aggressive behavior.
CAS:
77145-51-8
Formula:
C10H14ClN3
Molecular Weight:
211.69
Purity:
0.98
SMILES:
NC1CCN(CC1)c1cccc(Cl)n1
References
1. Kojima SI, Kojima K, Fujita T. Investigation of 5-HT(3) receptor-triggered serotonin release from guinea-pig isolated colonic mucosa: a role of PYY-containing endocrine cell. Eur J Pharmacol. 2017 Mar 15;799:196-200. doi: 10.1016/j.ejphar.2017.02.011. Epub 2017 Feb 9. PubMed PMID: 28189582.
2. Riga MS, S?nchez C, Celada P, Artigas F. Involvement of 5-HT3 receptors in the action of vortioxetine in rat brain: Focus on glutamatergic and GABAergic neurotransmission. Neuropharmacology. 2016 Sep;108:73-81. doi: 10.1016/j.neuropharm.2016.04.023. Epub 2016 Apr 20. PubMed PMID: 27106166.
3. Shimizu K, Kurosawa N, Seki K. The role of the AMPA receptor and 5-HT(3) receptor on aggressive behavior and depressive-like symptoms in chronic social isolation-reared mice. Physiol Behav. 2016 Jan 1;153:70-83. doi: 10.1016/j.physbeh.2015.10.026. Epub 2015 Nov 3. PubMed PMID: 26522741.
4. Leiser SC, Iglesias-Bregna D, Westrich L, Pehrson AL, Sanchez C. Differentiated effects of the multimodal antidepressant vortioxetine on sleep architecture: Part 2, pharmacological interactions in rodents suggest a role of serotonin-3 receptor antagonism. J Psychopharmacol. 2015 Oct;29(10):1092-105. doi: 10.1177/0269881115592347. Epub 2015 Jul 14. PubMed PMID: 26174134; PubMed Central PMCID: PMC4579402.