Streptomyces A-Factor
| Code | Size | Price |
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| TAR-T28869-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Streptomyces A-Factor is a microbial hormone found in Streptomyces griseus. A-factor triggers streptomycin biosynthesis and cell differentiation by binding a repressor-type receptor protein (ArpA) and dissociating it from DNA.
CAS:
51311-41-2
Formula:
C13H22O4
Molecular Weight:
242.315
Purity:
0.98
SMILES:
CC(C)CCCCC(=O)C1[C@H](CO)COC1=O
References
1. Matselyukh B, Mohammadipanah F, Laatsch H, Rohr J, Efremenkova O, Khilya V. N-methylphenylalanyl-dehydrobutyrine diketopiperazine, an A-factor mimic that restores antibiotic biosynthesis and morphogenesis in Streptomyces globisporus 1912-B2 and Streptomyces griseus 1439. J Antibiot (Tokyo). 2015 Jan;68(1):9-14. doi: 10.1038/ja.2014.86. Epub 2014 Jul 9. PubMed PMID: 25005816.
2. Hara O, Beppu T. Induction of streptomycin-inactivating enzyme by A-factor in Streptomyces griseus. J Antibiot (Tokyo). 1982 Sep;35(9):1208-15. PubMed PMID: 6292150.
3. Yao MD, Ohtsuka J, Nagata K, Miyazono K, Zhi Y, Ohnishi Y, Tanokura M. Complex structure of the DNA-binding domain of AdpA, the global transcription factor in Streptomyces griseus, and a target duplex DNA reveals the structural basis of its tolerant DNA sequence specificity. J Biol Chem. 2013 Oct 25;288(43):31019-29. doi: 10.1074/jbc.M113.473611. Epub 2013 Sep 9. PubMed PMID: 24019524; PubMed Central PMCID: PMC3829415.
4. Chi WJ, Jin XM, Jung SC, Oh EA, Hong SK. Characterization of Sgr3394 produced only by the A-factor-producin Streptomyces griseus IFO 13350, not by the A-factor deficient mutant. J Microbiol. 2011 Feb;49(1):155-60. doi: 10.1007/s12275-011-0330-z. Epub 2011 Mar 3. PubMed PMID: 21369994.