Tak 187
| Code | Size | Price |
|---|
| TAR-T28914-5mg | 5mg | £1,332.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T28914-50mg | 50mg | £2,625.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T28914-100mg | 100mg | £3,524.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Tak 187 is a long-lasting inhibitor of ergosterol biosynthesis.
CAS:
155432-64-7
Formula:
C23H20F6N6O3
Molecular Weight:
542.442
Purity:
0.98
SMILES:
CC(n1ncn(-c2ccc(OCC(F)(F)C(F)F)cc2)c1=O)C(O)(Cn1cncn1)c1ccc(F)cc1F
References
1. Corrales M, Cardozo R, Segura MA, Urbina JA, Basombr?o MA. Comparative efficacies of TAK-187, a long-lasting ergosterol biosynthesis inhibitor, and benznidazole in preventing cardiac damage in a murine model of Chagas' disease. Antimicrob Agents Chemother. 2005 Apr;49(4):1556-60. PubMed PMID: 15793138; PubMed Central PMCID: PMC1068647.
2. Urbina JA, Payares G, Sanoja C, Molina J, Lira R, Brener Z, Romanha AJ. Parasitological cure of acute and chronic experimental Chagas disease using the long-acting experimental triazole TAK-187. Activity against drug-resistant Trypanosoma cruzi strains. Int J Antimicrob Agents. 2003 Jan;21(1):39-48. PubMed PMID: 12507836.
3. Urbina JA. Specific treatment of Chagas disease: current status and new developments. Curr Opin Infect Dis. 2001 Dec;14(6):733-41. Review. PubMed PMID: 11964893.
4. Kitazaki T, Tasaka A, Hosono H, Matsushita Y, Itoh K. Optically active antifungal azoles. IX. An alternative synthetic route for 2-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4- triazol-1-yl)propyl]-4-[4-(2,2,3,3-tetrafluoropropoxy)phenyl]- 3(2H,4H)-1,2,4-triazolone and its analogs. Chem Pharm Bull (Tokyo). 1999 Mar;47(3):360-8. PubMed PMID: 10212386.