TAK-637
Code | Size | Price |
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TAR-T28917-5mg | 5mg | £1,251.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T28917-50mg | 50mg | £2,464.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T28917-100mg | 100mg | £3,283.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
TAK-637 is a tachykinin 1 (NK1) receptor antagonist.
CAS:
217185-75-6
Formula:
C30H25F6N3O2
Molecular Weight:
573.539
Purity:
0.98
SMILES:
C[C@@H]1CCn2c(c(-c3ccc(C)cc3)c3cccnc3c2=O)C(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C1
References
1. Tarui N, Ikeura Y, Natsugari H, Nakahama K. Microbial synthesis of three metabolites of a tachykinin receptor antagonist, TAK-637. J Biosci Bioeng. 2001;92(3):285-7. PubMed PMID: 16233097.
2. Venkova K, Greenwood-Van Meerveld B. Effects of TAK-637 on NK(1) receptor-mediated mechanisms regulating colonic secretion. Toxicol Appl Pharmacol. 2004 Apr 15;196(2):215-22. PubMed PMID: 15081268.
3. Furness JB. TAK-637. Takeda. Curr Opin Investig Drugs. 2001 Oct;2(10):1437-40. Review. PubMed PMID: 11890361.
4. Venkova K, Sutkowski-Markmann DM, Greenwood-Van Meerveld B. Peripheral activity of a new NK1 receptor antagonist TAK-637 in the gastrointestinal tract. J Pharmacol Exp Ther. 2002 Mar;300(3):1046-52. PubMed PMID: 11861814.