Terlakiren
| Code | Size | Price |
|---|
| TAR-T28950-5mg | 5mg | £1,155.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T28950-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T28950-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Terlakiren is a renin inhibitor.
CAS:
119625-78-4
Formula:
C31H48N4O7S
Molecular Weight:
620.81
Purity:
0.98
SMILES:
CSC[C@H](N([C@@H](CC1CCCCC1)[C@@H](O)C(=O)OC(C)C)C(=O)[C@H](Cc1ccccc1)NC(=O)N1CCOCC1)C(N)=O
References
1. Mangiapane ML, Peters BR. Role of nitric oxide in responses to renin-angiotensin system inhibition in sodium-depleted guinea pig and rat. Clin Exp Hypertens. 1998 Feb;20(2):141-63. PubMed PMID: 9533611.
2. Allen MC, Stafford CG, Nocerini MR. Quantitation of 4-cyclohexyl-2-hydroxy-3-(3-methylsulfanyl-2- [2-[(morpholine-4-carbonyl)amino]-3-phenylpropionylamino]propi onylamino ) butyric acid isopropyl ester (CP-80,794), a renin inhibitor, and its hydrolytic cleavage metabolite 2-[(morpholine-4-carbonyl)amino]-3-phenylpropionic acid (CP-84,364) in dog and human plasma by high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl. 1997 Aug 29;696(2):243-51. PubMed PMID: 9323544.
3. Shannon RP, Friedrich S, Mathier M, Knight DR. Effects of renin inhibition compared to angiotensin converting enzyme inhibition in conscious dogs with pacing-induced heart failure. Cardiovasc Res. 1997 Jun;34(3):464-72. PubMed PMID: 9231029.
4. Pitts JE, Crawford MD, Nugent PG, Wester RT, Cooper JB, Mantyla A, Fagerstrom R, Nevalainen H. The three-dimensional X-ray crystal structure of the aspartic proteinase native to Trichoderma reesei complexed with a renin inhibitor CP-80794. Adv Exp Med Biol. 1995;362:543-7. PubMed PMID: 8540369.