Thiolactomycin
| Code | Size | Price |
|---|
| TAR-T28964-5mg | 5mg | £1,332.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T28964-50mg | 50mg | £2,625.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T28964-100mg | 100mg | £3,524.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Thiolactomycin is a novel reversible dual inhibitor of D-amino acid oxidase (DAO) and D-Aspartate oxidase (DDO).
CAS:
82079-32-1
Formula:
C11H14O2S
Molecular Weight:
210.29
Purity:
0.98
SMILES:
CC(C=C)=C/[C@@]1(C)SC(O)=C(C)C1=O
References
1. Durairaj DR, Shanmughavel P. In Silico Drug Design of Thiolactomycin Derivatives Against Mtb-KasA Enzyme to Inhibit Multidrug Resistance of Mycobacterium tuberculosis. Interdiscip Sci. 2017 Aug 30. doi: 10.1007/s12539-017-0257-0. [Epub ahead of print] PubMed PMID: 28856604.
2. Li J, Tang X, Awakawa T, Moore BS. Enzymatic C-H Oxidation-Amidation Cascade in the Production of Natural and Unnatural Thiotetronate Antibiotics with Potentiated Bioactivity. Angew Chem Int Ed Engl. 2017 Sep 25;56(40):12234-12239. doi: 10.1002/anie.201705239. Epub 2017 Sep 1. PubMed PMID: 28833969; PubMed Central PMCID: PMC5673260.
3. Tang X, Li J, Moore BS. Minimization of the Thiolactomycin Biosynthetic Pathway Reveals that the Cytochrome P450 Enzyme TlmF Is Required for Five-Membered Thiolactone Ring Formation. Chembiochem. 2017 Jun 19;18(12):1072-1076. doi: 10.1002/cbic.201700090. Epub 2017 May 11. PubMed PMID: 28393452; PubMed Central PMCID: PMC5574029.
4. Yurkovich ME, Jenkins R, Sun Y, Tosin M, Leadlay PF. The polyketide backbone of thiolactomycin is assembled by an unusual iterative polyketide synthase. Chem Commun (Camb). 2017 Feb 9;53(13):2182-2185. doi: 10.1039/c6cc09934c. PubMed PMID: 28124037.