TZD18
| Code | Size | Price |
|---|
| TAR-T29028-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T29028-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T29028-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
TZD18, a novel PPAR alpha/gamma dual agonist, inhibits cell growth and induces apoptosis in human glioblastoma T98G cells.
CAS:
228577-00-2
Formula:
C27H27NO5S
Molecular Weight:
477.58
Purity:
0.98
SMILES:
CCCc1cc(Oc2ccccc2)ccc1OCCCOc1cccc(c1)C1SC(=O)NC1=O
References
1. Zang C, Liu H, Bertz J, Possinger K, Koeffler HP, Elstner E, Eucker J. Induction of endoplasmic reticulum stress response by TZD18, a novel dual ligand for peroxisome proliferator-activated receptor alpha/gamma, in human breast cancer cells. Mol Cancer Ther. 2009 Aug;8(8):2296-307. doi: 10.1158/1535-7163.MCT-09-0347. Epub 2009 Aug 11. PubMed PMID: 19671747.
2. Zang C, Liu H, Waechter M, Eucker J, Bertz J, Possinger K, Koeffler HP, Elstner E. Dual PPARalpha/gamma ligand TZD18 either alone or in combination with imatinib inhibits proliferation and induces apoptosis of human CML cell lines. Cell Cycle. 2006 Oct;5(19):2237-43. Epub 2006 Oct 1. PubMed PMID: 17102607.
3. Liu H, Zang C, Fenner MH, Liu D, Possinger K, Koeffler HP, Elstner E. Growth inhibition and apoptosis in human Philadelphia chromosome-positive lymphoblastic leukemia cell lines by treatment with the dual PPARalpha/gamma ligand TZD18. Blood. 2006 May 1;107(9):3683-92. Epub 2006 Jan 10. PubMed PMID: 16403907.
4. Liu DC, Zang CB, Liu HY, Possinger K, Fan SG, Elstner E. A novel PPAR alpha/gamma dual agonist inhibits cell growth and induces apoptosis in human glioblastoma T98G cells. Acta Pharmacol Sin. 2004 Oct;25(10):1312-9. PubMed PMID: 15456533.