U-7524
| Code | Size | Price |
|---|
| TAR-T29033-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T29033-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T29033-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
U-7524, also known as AOAA and Aminooxyacetic acid, is an inhibitor of 4-aminobutyrate aminotransferase (GABA-T). AOAA is also a general inhibitor of pyridoxal phosphate (PLP)-dependent enzymes (this includes GABA-T). It functions as an inhibitor by attacking the Schiff base linkage between PLP and the enzyme, forming oxime type complexes.
CAS:
645-88-5
Formula:
C2H5NO3
Molecular Weight:
91.066
Purity:
0.98
SMILES:
NOCC(O)=O
References
1. Carmona E, Gomes C, Trolin G. Effect of aminooxyacetic acid (AOAA) on GABA levels in some parts of the rat brain. Naunyn Schmiedebergs Arch Pharmacol. 1980 May;312(1):51-5. PubMed PMID: 7393347.
2. Duvilanski BH, Seilicovich A, D?az MC, Mu?oz Maines V, Lasaga M, Deb?ljuk L. Effect of GABA-T inhibitors on prolactin secretion in vitro. Eur J Pharmacol. 1985 Sep 10;115(1):65-9. PubMed PMID: 4043235.
3. Neal MJ, Starr MS. Effect of inhibitors of -aminobutyrate aminotransferase on the accumulation of 3H- -aminobutyric acid by the retina. Br J Pharmacol. 1973 Mar;47(3):543-55. PubMed PMID: 4730831; PubMed Central PMCID: PMC1776273.
4. van der Laan JW, Weick G, van Bleek G. Effects of inhibitors of GABA-transaminase on hole-board exploration and on temperature. Relation with effects on quasi-morphine abstinence behaviour induced by sodium dipropylacetate. Biochem Pharmacol. 1985 Nov 1;34(21):3789-94. PubMed PMID: 3933514.